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Phthalates are a group of ubiquitous synthetic endocrine-disrupting chemicals. Fetal and neonatal periods are particularly susceptible to endocrine disorders, which prenatal exposure to phthalates causes. There is increasing evidence concerning the potential endocrine disrupting for phthalate exposure during pregnancy. Prenatal exposure phthalates would disrupt the level of sex hormone in pregnant women, which results in preeclampsia. The relationship of prenatal phthalate exposure with maternal and neonatal outcomes in human beings was often sex-specific associations. Because of the potentially harmful influence of prenatal phthalate exposure, steps should be taken to prevent or reduce phthalate exposure during pregnancy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| healthy pregnant woman | pregnant woman without any disease of pregnancy |
| |
| pregnant woman with preeclampia | pregnant woman with preeclampia but without any other disease of pregnancy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| test Phthalates, estrogen and progesterone | Other | test mothers Phthalates in their urine, and test estrogen and progesterone receptor in placental tissue |
|
| Measure | Description | Time Frame |
|---|---|---|
| Phthalates in urine | Collect the urine of pregnant women and test the abundance of Phthalates | 37 weeks to 40 weeks gestation |
| Measure | Description | Time Frame |
|---|---|---|
| The female progesterone | Collect the placenta tissue of pregnant women and test the abundance of estrogen progesterone receptor | 37 weeks to 40 weeks gestation |
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Inclusion Criteria:
Exclusion Criteria:
Eligible participants is female.
The participants include pregnant women meeting the inclusion criteria.
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| Name | Affiliation | Role |
|---|---|---|
| Ying Hua | Second Affiliated Hospital of Wenzhou Medical University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| department of obstetrics of Second Affiliated Hospital of Wenzhou Medical University | Wenzhou | Zhejiang | 325027 | China |
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| ID | Term |
|---|---|
| D011225 | Pre-Eclampsia |
| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D004967 | Estrogens |
| D011374 | Progesterone |
| ID | Term |
|---|---|
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D045505 | Physiological Effects of Drugs |
| D020228 | Pharmacologic Actions |
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| D020164 | Chemical Actions and Uses |
| D011282 | Pregnenediones |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D003339 | Corpus Luteum Hormones |
| D042341 | Gonadal Hormones |
| D045167 | Progesterone Congeners |
| D012739 | Gonadal Steroid Hormones |