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The Efficacy and Safety of Dezocine Pretreatment for Pain Relief in Acne Scar Treatment of Fractional CO2 Laser
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group | Placebo Comparator | The patients were divided into 3 groups based on different dosages of Dezocine injection, with 35 patients in each group: Group 1: Dezocine low-dose group, Group 2: Dezocine high-dose group; Group 3: Blank control group (normal saline). |
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| Dezocine low dose group | Experimental | The patients were divided into 3 groups based on different dosages of Dezocine injection, with 35 patients in each group: Group 1: Dezocine low-dose group, Group 2: Dezocine high-dose group; Group 3: Blank control group (normal saline). |
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| Dezocine high dose group | Experimental | The patients were divided into 3 groups based on different dosages of Dezocine injection, with 35 patients in each group: Group 1: Dezocine low-dose group, Group 2: Dezocine high-dose group; Group 3: Blank control group (normal saline). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fractional CO2 laser | Device | All patients were given oral administration of 0.5mg paronosetron hydrochloride and lidocaine cream 1 hour before surgery. After cleaning and disinfection, fractional CO2 laser treatment was given. Among them, the fractional CO2 laser laser (American Medical Laser company) selected relatively constant energy parameters in the treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Visual Analog Score for Pain | 0 was classified as painless and 10 was classified as unbearable pain. Marks were made on the corresponding parts of the ruler and scores were scored according to the degree of patient's feeling | 24 hours |
| Hemodynamic parameters | diastolic blood pressure (DBP), systolic blood pressure (SBP) | 24 hours |
| Heart rate (HR) | Hemodynamic parameters | 24 hours |
| oxygen saturation (SpO2) | Hemodynamic parameters | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Occurrence of Adverse Reactions | Nausea, vomiting，dizziness，respiratory depression | 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
Those who take sedative drugs for a long time;
Patients with sleep apnea syndrome, previous history of hypertension, and blood pressure greater than 160/100mmHg
People with severe heart and lung diseases, liver and kidney diseases, psychosis, pregnancy, and communication disorders;
Persons who are known to be allergic to the main drug or any of the excipients in Dezocine injection;
Increased intracranial pressure or head injury;
Acute and chronic alcoholism;
People with hypotension, hypothyroidism, acute episodes of asthma, and epilepsy
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chen Yu, MD | Contact | 13571991903 | 86 | ycyc_2005@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Gang Wang, Prof | Dermatology Derpartment of Xijing Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dermatology Derpartment of Xijing Hospital | Recruiting | Xi'an | Shaanxi | 710032 | China |
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| ID | Term |
|---|---|
| C010827 | dezocine |
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| Dezocine | Drug | Desocine injection was injected intravenously half an hour before surgery (10ml normal saline was added for more than 30 seconds) |
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