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Postoperative pain management is considered an integral part of perioperative care in patients undergoing thoracotomy. In order to reduce these complications, multiple regional techniques have been developed for thoracotomy including Intercostal nerve block, Erectospinae plane block and serratus block. Multiple adjuvants have been used in regional analgesia including adrenaline,clonidine,magnesium sulphate,dexmedatomidine and opoids.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Erector spinae plane block with 0.25% bupivacaine | Active Comparator | Patients will receive ultrasound guided ESPB with 0.25% bupivacaine |
|
| Erector spinae plane block with 0.25% bupivacaine and Magnesium | Experimental | Patients will receive ultrasound guided ESPB with 0.25% bupivacaine and magnesium |
|
| Erector spinae plane block with 0.25% bupivacaine and Dexmedetomidine | Experimental | Patients will receive ultrasound guided ESPB with 0.25% bupivacaine and dexmedetomidine |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bupivacaine | Drug | Bupivacaine 0.25% |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Total postoperative morphine consumption | Total dose of morphine needed postoperatively in the first 24 h | First 24 hours postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Time to first postoperative rescue analgesia. | Time to first postoperative rescue analgesia. | First 24 hours postoperatively |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Walaa Y Elsabeeny, MD | Contact | 01007798466 | +2 | walaa.elsabeeny@nci.cu.edu.eg |
| Ahmed A Mohamed, MD | Contact | 01272222923 | +2 | ahmed.aboali7268@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Walaa Y Elsabeeny, MD | Assistant professor of Anesthesia and Pain Management, National Cancer Institute, Cairo University | Principal Investigator |
| Ahmed A Mohamed, MD | Professor of Anesthesia,Surgical intensive care and Pain management,Faculty of medicine |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Walaa Y Elsabeeny | Recruiting | Cairo | 11796 | Egypt |
Information is available upon reasonable request through contacting the corresponding investigator
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| ID | Term |
|---|---|
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| D008274 | Magnesium |
| D020927 | Dexmedetomidine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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Double blinded
| Bupivacaine + Magnesium |
| Drug |
Bupivacaine 0.25% + Magnesium |
|
| Bupivacaine + Dexmedetomidine | Drug | Bupivacaine 0.25% + Dexmedetomidine |
|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D000588 |
| Amines |
| D008673 | Metals, Alkaline Earth |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D019565 | Metals, Light |
| D008670 | Metals |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |