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A lot of different early and late complications may occur after liver transplantation. They could be related to surgical procedure, to infectious diseases or immuno-mediated diseases (acute cellular rejection, ACR). Almost all of those complications are characterized by an elevation in liver enzymes (ALT, AST and GGT) and a decline of liver function tests (serum bilirubin and INR increase) possibly leading to early allograft disfunction (EAD). In this scenario there is a lack of biomarker that could predict the development of ACR and/or EAD.
The aim of this study is to explore the prognostic role of non-invasive instrumental and biological marker in the early post-transplant phase.
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| Measure | Description | Time Frame |
|---|---|---|
| Early Allograft dysfunction (EAD) | Olthoff criteria: bilirubina≥ 10 mg/dL in 7th post-operative day, international normalized ratio (INR) ≥ 1.6 in 7th post-operative day 7; ALT or AST> 2000 IU/L during the first 7 days after liver transplantation | 2 weeks from Liver transplantation |
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Inclusion Criteria:
Exclusion Criteria:
No agreement or inability to give informed consent
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Patients eligible for liver transplantation
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Luca Miele, MD, PhD | Contact | +390630151 | luca.miele@policlinicogemelli.it |
| Name | Affiliation | Role |
|---|---|---|
| Antonio Liguori, MD | Catholic University of the Sacred Heart | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fondazione Policlinico Universitario A. Gemelli IRCCS | Recruiting | Rome | 00181 | Italy |
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| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| ID | Term |
|---|---|
| D004066 | Digestive System Diseases |
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