The main focus of this study is to develop blood and/or urine tests that will help to detect early signs of rejection in people who have had a liver transplant. Researchers will examine blood, urine, and tissue samples and try to identify markers for certain conditions such as rejection, response to therapy, and scarring of the liver. Additionally, researchers would like to identify biomarkers that can detect damage to the native kidneys before blood levels of creatinine rises. By studying gene expression, researchers hope to be able to diagnose these conditions earlier and improve liver survival.

Inclusion Criteria:

• Subjects undergoing primary deceased-donor or living donor liver transplantation;
• Subject must be able to understand and provide informed consent.

Exclusion Criteria:

• Need for combined organ transplantation;
• Previous solid organ and/or islet cell transplantation;
• Infection with HIV;
• Allergy to iodine;
• Inability or unwillingness of a participant to comply with study protocol;
• Any condition that, in the opinion of the investigator, would interfere with the participant's ability to comply with study requirements.

Liver Transplant Recipients

The plan is to share data in ImmPort, a long-term archive of clinical and mechanistic data from DAIT-funded grants and contracts that also provides data analysis tools that are available to researchers who register online and subsequently receive DAIT approval.