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| Name | Class |
|---|---|
| Sytheon Ltd. | INDUSTRY |
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The purpose of this study is to asses the impact of topically applying a form of vitamin C known as tetrahexyldecyl Ascorbate (THDA) along with a novel anti-aging ingredient, acetyl zingerone, compared against applying THDA alone.
In this study, we examine the effects of adding acetyl zingerone to vitamin-C derived ester THDA on its effects on the signs of photoaging (redness, uneven skin tone, and the appearance of fine lines) and compare it to the effects of applying THDA alone.
Acetyl zingerone is derived from ginger and has anti-oxidant properties
In this study, participants will be randomized to either receiving a THDA + acetyl zingerone product or a THDA only product.
This means that you will have an equal chance of receiving either product. You and the research team will not know which product you have been randomized to received because the products will be labelled with a code. The research team will only know which product contained THDA + acetyl zingerone and which product contained only THDA at the end of the study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| THDA + Acetyl Zingerone | Experimental | Product will be used twice daily- once in the morning and once in the evening for 8 weeks. Each application will consist of 1-2 pumps (size of quarter) onto the face and neck, until fully absorbed. |
|
| THDA only | Active Comparator | Product will be used twice daily- once in the morning and once in the evening for 8 weeks. Each application will consist of 1-2 pumps (size of quarter) onto the face and neck, until fully absorbed. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| THDA + Acetyl Zingerone Topical Product | Other | A skin care product with Acetyl Zingerone (Synoxyl® AZ) and THDA (VitaSynol® C) used twice daily |
|
| Measure | Description | Time Frame |
|---|---|---|
| Facial fine lines and wrinkles | Change in severity of fine lines and wrinkles measured by photographic analysis (BTBP 3D Camera System) | 8 weeks |
| Facial skin pigment evenness | Change in the appearance of facial skin pigment intensity measured by photographic analysis (BTBP 3D Camera System) | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Facial fine lines and wrinkles | Change in severity of fine lines and wrinkles measured by photographic analysis (BTBP 3D Camera System) | 4 weeks |
| Facial skin pigment evenness | Change in the appearance of facial skin pigment intensity measured by photographic analysis (BTBP 3D Camera System) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Integrative Skin Science and Research | Sacramento | California | 95815 | United States |
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| ID | Term |
|---|---|
| D010859 | Pigmentation Disorders |
| ID | Term |
|---|---|
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| THDA | Other | A skin care product with THDA (VitaSynol® C) used twice daily |
|
| 4 weeks |
| Skin redness | Change in the appearance of skin redness measured by photographic analysis (BTBP 3D Camera System) | 4 weeks |
| Skin redness | Change in the appearance of skin redness measured by photographic analysis (BTBP 3D Camera System) | 8 weeks |
| Change in skin pigmentation in the undereye area | hange in skin pigmentation in the undereye area by Skin colorimetric analysis of pigment | 4 weeks |
| Change in skin pigmentation in the undereye area | hange in skin pigmentation in the undereye area by Skin colorimetric analysis of pigment | 8 weeks |
| Self-perception of skin parameters | Survey based self-assessment of facial features such as fine lines and wrinkles, skin smoothness, skin firmness | 4 weeks |
| Self-perception of skin parameters | Survey based self-assessment of facial features such as fine lines and wrinkles, skin smoothness, skin firmness | 8 weeks |
| Tolerability of product | Questionnaire based self-assessment about the tolerability of the topical skin product | 4 weeks |
| Tolerability of product | Questionnaire based self-assessment about the tolerability of the topical skin product | 8 weeks |