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The purpose of this study is to determine the clinical efficacy of a combination of Astaxanthin (2 mg), Lycopene (1.8 mg), and d-alpha-Tocopherol (10 IU) in terms of its skin anti-aging properties. Specifically, the investigators aim to determine the increase in hydration levels of the skin, decrease in atypical skin pigmentation, and reduction of signs of photoaging, particularly facial fine lines.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Astaxanthin (2mg)+Lycopene (1.8mg)+D-Alpha-Tocopherol (10IU) | Experimental |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Astaxanthin (2mg)+Lycopene (1.8mg)+D-Alpha-Tocopherol (10IU) | Dietary Supplement | The intervention is to be taken once daily, for 12 weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of subjects within each treatment group with a significant decrease in skin wrinkling measured by a validated Crow's Feet Wrinkle scale. | The scale ratings are 0 for no wrinkles, 1 for very fine wrinkles, 2 for fine wrinkles, 3 for moderate wrinkles, and 4 for severe wrinkles. | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of subjects within each treatment group with a significant increase in skin hydration measured by a corneometer. | 12 weeks | |
| Proportion of subjects within each treatment group with a significant decrease in pigmentation measured by a mexameter. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| PDC Building, 1440 Taft Avenue | Manila | National Capital Region | Philippines |
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| ID | Term |
|---|---|
| C005948 | astaxanthine |
| D000077276 | Lycopene |
| D024502 | alpha-Tocopherol |
| ID | Term |
|---|---|
| D002338 | Carotenoids |
| D011090 | Polyenes |
| D000475 | Alkenes |
| D006839 | Hydrocarbons, Acyclic |
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| Placebo | Dietary Supplement | The intervention is to be taken once daily, for 12 weeks. |
|
| 12 weeks |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D053138 | Cyclohexenes |
| D003510 | Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
| D006844 | Hydrocarbons, Cyclic |
| D013729 | Terpenes |
| D010860 | Pigments, Biological |
| D001685 | Biological Factors |
| D024505 | Tocopherols |
| D014810 | Vitamin E |
| D001578 | Benzopyrans |
| D011714 | Pyrans |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |