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From the operation list, patients that meet the Inclusion criteria will be selected. (n=60)
Patients will be allocated into two participant groups. Group I and Group II respectively using Simple random sampling technique by Ballot method. Ballot method is to keep the list of patients that meet the inclusion criteria in two ballot box mentioning name and groups and do the lottery based selection for both groups and Patient code will be given.
Group I (n = 30) Preloading with Ringer Lactate 30 ml/kg over 30 mins prior to surgery will be done and Propofol dose (2mg / kg ) requirement for induction of anaesthesia will be noted.
Group II (n = 30) No Preloading will be done and Propofol dose (2mg / kg) requirement for induction of anaesthesia will be noted.
Then, investigators will visualize for loss of eyelash reflex in both groups.
The hemodynamic response (heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure) to intubation between the two participant groups will be noted. The total Propofol requirement for induction in Ringer Lactate preloaded versus control group will be recorded.
Drug administration and parameters recording will be done by the anaesthesiologist / under supervision
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group I (Preloading with Ringer Lactate) | Experimental | Preloading with Ringer lactate 30ml/kg over 30 minutes prior to surgery and Propofol dose requirement for induction of anaesthesia will be noted |
|
| Group II (No preloading) | No Intervention | No preloading will be done and Propofol dose requirement for induction of anaesthesia will be noted |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ringer Lactate prior to surgery and Propofol | Drug | Ringer Lactate prior to surgery and Propofol dose requirement for induction of anaesthesia will be noted |
|
| Measure | Description | Time Frame |
|---|---|---|
| Propofol dose Required (mg) | Propofol dose (mg) with aspect to weight (kg) | Standard dosing in Operation |
| Total Propofol dose given (mg) | Propofol dose (mg) | Visualization of loss of eyelash reflex |
| Loss of eyelash reflex (seconds) | Visualization of loss of eyelash reflex (seconds) | Propofol given till loss of eyelash reflex |
| Measure | Description | Time Frame |
|---|---|---|
| Units of Measure (e.g., weight and height) | Weight in kilograms, height in meters ( weight and height will be combined to report BMI in kg/m²). | Preanaesthetic checkup, Day 1 |
| Heart rate (beats / minute): After IV Propofol |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dr Arushi Jaiswal | Contact | +9779841675096 | arushij.dr16@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Medical College Teaching Hospital | Recruiting | Birgunj | Madhesh | 44300 | Nepal |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 7943815 | Result | Smith I, White PF, Nathanson M, Gouldson R. Propofol. An update on its clinical use. Anesthesiology. 1994 Oct;81(4):1005-43. No abstract available. | |
| 8214693 | Result | Hug CC Jr, McLeskey CH, Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF, Apfelbaum JL, Grasela TH, et al. Hemodynamic effects of propofol: data from over 25,000 patients. Anesth Analg. 1993 Oct;77(4 Suppl):S21-9. |
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| ID | Term |
|---|---|
| D015742 | Propofol |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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|
Heart rate (beats / minute) will be measured with pulse oxymeter
| Immediately After IV Propofol |
| Heart rate (beats / minute): Baseline before IV fluid infusion | Heart rate (beats / minute) will be measured with pulse oxymeter | Base line Before IV fluid infusion |
| Heart rate (beats / minute): At intubation (0 minute) | Heart rate (beats / minute) will be measured with pulse oxymeter | At intubation (0 minute) |
| Heart rate (beats / minute): Post intubation (1 minute) | Heart rate (beats / minute) will be measured with pulse oxymeter | Post intubation (1 minute) |
| Heart rate (beats / minute): Post intubation (3 minute) | Heart rate (beats / minute) will be measured with pulse oxymeter | Post intubation (3 minute) |
| Heart rate (beats / minute): Post intubation (5 minute) | Heart rate (beats / minute) will be measured with pulse oxymeter | Post intubation (5 minute) |
| Heart rate (beats / minute): Post intubation (10 minute) | Heart rate (beats / minute) will be measured with pulse oxymeter | Post intubation (10 minute) |
| Systolic blood pressure (mm Hg): Baseline before IV fluid infusion | Systolic blood pressure (mm Hg) will be recorded on vital monitor | Baseline before IV fluid infusion |
| Systolic blood pressure (mm Hg): After IV Propofol | Systolic blood pressure (mm Hg) will be recorded on vital monitor | Immediately After IV Propofol |
| Systolic blood pressure (mm Hg): At intubation (0 minute) | Systolic blood pressure (mm Hg) will be recorded on vital monitor | At intubation (0 minute) |
| Systolic blood pressure (mm Hg): Post intubation (1 minute) | Systolic blood pressure (mm Hg) will be recorded on vital monitor | Post intubation (1 minute) |
| Systolic blood pressure (mm Hg): Post intubation (3 minute) | Systolic blood pressure (mm Hg) will be recorded on vital monitor | Post intubation (3 minute) |
| Systolic blood pressure (mm Hg): Post intubation (5 minute) | Systolic blood pressure (mm Hg) will be recorded on vital monitor | Post intubation (5 minute) |
| Systolic blood pressure (mm Hg): Post intubation (10 minute) | Systolic blood pressure (mm Hg) will be recorded on vital monitor | Post intubation (10 minute) |
| Diastolic blood pressure (mm Hg): Baseline before IV fluid infusion | Diastolic blood pressure (mm Hg) will be recorded on vital monitor | Baseline before IV fluid infusion |
| Diastolic blood pressure (mm Hg): After IV Propofol | Diastolic blood pressure (mm Hg) will be recorded on vital monitor | Immediately After IV Propofol |
| Diastolic blood pressure (mm Hg): At intubation (0 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor | At intubation (0 minute) |
| Diastolic blood pressure (mm Hg): Post intubation (1 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor | Post intubation (1 minute) |
| Diastolic blood pressure (mm Hg): Post intubation (3 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor | Post intubation (3 minute) |
| Diastolic blood pressure (mm Hg): Post intubation (5 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor | Post intubation (5 minute) |
| Diastolic blood pressure (mm Hg): Post intubation (10 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor | Post intubation (10 minute) |
| Mean arterial pressure (mm Hg): After IV Propofol | Diastolic blood pressure (mm Hg) will be recorded on vital monitor | Immediately After IV Propofol |
| Mean arterial pressure (mm Hg): Baseline before IV fluid infusion | Diastolic blood pressure (mm Hg) will be recorded on vital monitor | Baseline before IV fluid infusion |
| Mean arterial pressure (mm Hg): At intubation (0 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor | At intubation (0 minute) |
| Mean arterial pressure (mm Hg): Post intubation (1 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor | Post intubation (1 minute) |
| Mean arterial pressure (mm Hg): Post intubation (3 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor | Post intubation (3 minute) |
| Mean arterial pressure (mm Hg): Post intubation (5 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor | Post intubation (5 minute) |
| Mean arterial pressure (mm Hg): Post intubation (10 minute) | Diastolic blood pressure (mm Hg) will be recorded on vital monitor | Post intubation (10 minute) |
| 3257362 | Result | Van Aken H, Meinshausen E, Prien T, Brussel T, Heinecke A, Lawin P. The influence of fentanyl and tracheal intubation on the hemodynamic effects of anesthesia induction with propofol/N2O in humans. Anesthesiology. 1988 Jan;68(1):157-63. doi: 10.1097/00000542-198801000-00031. No abstract available. |
| 6978144 | Result | Briggs LP, Dundee JW, Bahar M, Clarke RS. Comparison of the effect of diisopropyl phenol (ICI 35, 868) and thiopentone on response to somatic pain. Br J Anaesth. 1982 Mar;54(3):307-11. doi: 10.1093/bja/54.3.307. |
| 3259081 | Result | McCollum JS, Milligan KR, Dundee JW. The antiemetic action of propofol. Anaesthesia. 1988 Mar;43(3):239-40. doi: 10.1111/j.1365-2044.1988.tb05551.x. |
| 10320158 | Result | Williams EL, Hildebrand KL, McCormick SA, Bedel MJ. The effect of intravenous lactated Ringer's solution versus 0.9% sodium chloride solution on serum osmolality in human volunteers. Anesth Analg. 1999 May;88(5):999-1003. doi: 10.1097/00000539-199905000-00006. |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |