Comparison of Different Propofol Formulations

Dose-effect of Propofol for Anesthetic Induction: Double-blind Comparison of Different Propofol Formulations Administered Alone or With Lidocaine

The objective of this study is to evaluate the influence of different propofol formulations(plain or with lidocaine)on anesthetic induction. Propofol plain or with lidocaine is administered using a closed-loop algorithm in order to reach a Bispectral Index target of 50.

Inclusion Criteria:

• patients scheduled for an intravenous induction of anesthesia with propofol

Exclusion Criteria:

• Age under 18
• Pregnancy or breastfeeding
• Allergy to propofol, soya or peanuts,
• Allergy to lidocaine,
• History of central neurological disorder or brain injury,
• Patients receiving psychotropic drugs,
• Patient with a pacemaker.