Pilot Study of Effect of Intravenous Lidocaine on Propofol Requirement in Facial Plastic Surgery

Pilot Study of Effect of Intravenous Lidocaine on Propofol Requirement During Monitored Anesthesia Care in Facial Plastic Surgery

The purpose of this randomized pilot study is to evaluate the effect of intravenous lidocaine on propofol requirement during BIS (Bispectral index) guided MAC (monitored anesthesia care) in facial plastic surgery.

Several studies reported the usefulness of intravenous lidocaine as a coadjuvant agent during general anesthesia. We thought that there would be an interaction between intravenous lidocaine and hypnotic agent requirement. However, there is no data regarding the effect of systemic lidocaine during MAC. We, thus, would like to perform a randomized, double-blinded pilot study to evaluate the effect of intravenous lidocaine on propofol requirement during BIS guided MAC in facial plastic surgery.

Inclusion Criteria:

• American Society of Anesthesiologists physical status classification 1 or 2 patients
• aged 20-65 years who were undergoing elective facial plastic surgery under monitored anesthesia care

Exclusion Criteria:

• unwillingness to participate in the study
• adverse reaction to the drugs used in the study
• use of medications that interfere in local anesthetic metabolism
• history of liver disease or kidney failure
• neurological or psychiatric disease
• history of drug or alcohol abuse
• chronic use of benzodiazepine