The aim of this study is to determine the effect of virtual reality glasses and ball squeezing method used during peripheral intravenous catheter placement on pain and anxiety.The hypotheses of this research are that virtual reality glasses and a stress ball reduces pain and anxiety.

This study was designed as a pretest-posttest regular parallel group, randomized controlled experimental. The research will be carried out in the general surgery clinic of Necmettin Erbakan University Meram Medical Faculty Hospital. Patients will be randomly assigned to three groups: ball squeezing (37), virtual reality glasses (37) and control group (37). For Virtual Reality Glasses Group: The video containing the nature walk will be watched by virtual reality. 3 minutes after the individual starts watching the video, the IV catheter insertion attempt will be performed while continuing to watch the video. For Ball Squeezing Group: Patients will be given a ball and instructed to tighten and loosen with their free hand during intravenöz catheter placement. The intravenöz catheter insertion attempt will be made while the patient continues to squeeze the ball. For Control Group: No application will be made during intravenous catheter placement in the control group.The primary outcome of this study was to determine the patients' pain scores during the peripheral venous cannula insertion process.The secondary outcomes of the study were to determine the patients' anxiety levels.

Inclusion Criteria:

• Admission to the General Surgery clinic.
• No verbal, perceptual and visual communication problems,
• Being between 18 - 65 years old,
• Being literate,
• Volunteer to participate in the research,
• Not using drugs that will create a chronic analgesic effect,
• Absence of chronic or acute pain,
• No intervention in the last month in the vein where an IV catheter was placed.
• The absence of scar tissue and infection in the areas to be used for IV catheter placement,
• It was determined as not having a disease (such as neuropathy) that would cause problems in feeling pain.

Exclusion Criteria:

• The individual's desire to leave the study,
• Inability to perform the ball squeezing motion,
• Feeling unwell during IV catheter placement (such as dizziness, palpitations),
• During use of VR, the patient experiences symptoms such as nausea and dizziness,
• Using sedatives or alcohol,

Termination criteria

• Failure of PIV catheter placement,

The patients will be informed about the study and their consent will be obtained without explaining which group they are in. Since the researcher manages the implementation process of the study, researcher blinding cannot be done. In addition, it will be ensured that the researcher learns which group the patients are in after the patients accept to participate in the study. Thus, the internal validity of the research will be ensured. Since data is collected from the patients in the sample group at the time of admission to the ward, interaction between patients will be prevented.

At the same time, blind technique will be applied in terms of statistical analysis in the research. The data will be recorded on the computer by the researcher without using the expression of experimental and control groups, and data analysis will be done by another statistician other than the person who made the randomization.