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This study will test whether consuming blueberry powder 20g/d for 24 weeks can improve memory and other cognitive function and alter serum biomarkers of brain injury among older adults.
In a randomized, double-blind placebo, controlled design, the investigators will test the effects of 20 g/d of blueberry powder for 24 weeks on cognitive function and serum biomarkers of brain injury among older adults.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Blueberry group | Active Comparator | Blueberry arm |
|
| Control group | Placebo Comparator | Control arm |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blueberry powder | Dietary Supplement | 20 g per day of blueberry powder |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change in plasma concentration of neurofilament light (NFL) between baseline and 24 weeks | Change will be calculated as difference between plasma NFL concentration measured at 24 weeks and NFL concentration measured at baseline. | Baseline and at 24 weeks after the intervention |
| Change in plasma concentration of phosphorylated tau (pTau-181) between baseline and 24 weeks | Change will be calculated as difference between plasma pTau-181 concentration measured at 24 weeks and plasma concentration of pTau-181 measured at baseline | Baseline and at 24 weeks post intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Change in plasma concentration of glial fibrillary acid protein (GFAB) between baseline and 24 weeks | Change will be calculated as difference between plasma concentration of GFAB measured at 24 weeks and plasma GFAB concentration measured at baseline | Baseline and at 24 weeks post intervention |
| Change in concentration of serum non-esterified fatty acids (NEFA) between baseline and 24 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mass General Brigham | Boston | Massachusetts | 02120 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42251891 | Derived | Guardino ET, Gabriel O, Mukamal KJ, Djousse L. Effects of a 24-week intervention with freeze-dried blueberries on brain health in older adults: A randomized double-blind, placebo-controlled trial. Clin Nutr ESPEN. 2026 Aug;74:103377. doi: 10.1016/j.clnesp.2026.103377. Epub 2026 Jun 6. |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| D001930 | Brain Injuries |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D001927 | Brain Diseases |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
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| Controlled and matched powder |
| Other |
20 g per day |
|
Change will be computed as difference between serum concentration of NEFA measured at 24 weeks and serum NEFA concentration measured at baseline |
| Baseline and 24 weeks post intervention |
| Change in cognitive battery test score between baseline and 24 weeks post intervention | The investigators will use CANTAB (computer-based and interactive software) to complete 8 cognitive battery tests including a) Motor screening task; b) Reaction time; c) Paired associates learning; d) Spatial working memory; e) Pattern recognition memory; f) Delayed matching to sample; g) Rapid visual information processing; and h) Match to sample visual search. The computer automatically calculates a composite score from these 8 tests (a-h) and the investigators will define change in cognitive battery test score as difference in composite score between 24 weeks and baseline. | Baseline and at 24 weeks post intervention |
| D002493 |
| Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D006259 | Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D008722 | Methods |