Long-term Effects of Blueberry Supplementation on Brain Health in Older Adults

Long-term Effects of Blueberry Supplementation on Brain Health in Older Adults: a Randomized Placebo-controlled Trial

This study will test whether consuming blueberry powder 20g/d for 24 weeks can improve memory and other cognitive function and alter serum biomarkers of brain injury among older adults.

In a randomized, double-blind placebo, controlled design, the investigators will test the effects of 20 g/d of blueberry powder for 24 weeks on cognitive function and serum biomarkers of brain injury among older adults.

Inclusion Criteria:

• Adults aged 65-99 years
• Able to travel to Brigham and Women's Hospital for 4 clinic visits

Exclusion Criteria:

• Known allergies to blueberries
• Unable to abstain from blueberry consumption during the study period
• Inability to provide informed consent
• Planned major surgery during study period or recent major surgery up to 3 months before recruitment
• Organ transplant
• Plan to move out of greater Boston area during the study period
• Diagnosis of dementia, severe cognitive decline, end-stage renal disease, substance abuse, insulin-dependent diabetes mellitus, major cancer excluding non-melanoma skin cancer, and schizophrenia.