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Blueberries are rich in flavonoids that possess antioxidant and anti-inflammatory properties, which in rodent models are neuro-protective. The risk of developing dementia is reduced in people habitually consuming high flavonoid intakes, but data from human intervention studies is sparse. We therefore investigated whether 12 weeks of blueberry concentrate supplementation improved cognitive function in healthy elderly via increased brain activation and perfusion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Blueberry | Active Comparator | Blueberry concentrate consumed daily for 12 weeks. |
|
| Placebo | Placebo Comparator | Placebo concentrate consumed daily for 12 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blueberry | Dietary Supplement |
| ||
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Brain perfusion | MRI - arterial spin labelling | Change from baseline to 12 weeks dietary supplementation |
| Measure | Description | Time Frame |
|---|---|---|
| Brain activation | fMRI whilst performing modified Stroop task | Change from baseline to 12 weeks dietary supplementation |
| Cognitive function tests | Cogstate battery of tests |
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Inclusion Criteria:
Exclusion Criteria:
Addenbrooke's Cognitive Examination III questionnaire < 88 Contraindications for MRI Consuming more than 5 portions of fruit per day
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| Name | Affiliation | Role |
|---|---|---|
| Joanna Bowtell, PhD | University of Exeter | Principal Investigator |
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| ID | Term |
|---|---|
| C000721609 | blueberry extract |
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| Change from baseline to 12 weeks dietary supplementation |
| Blood biomarkers of inflammation | CRP, IL6, | Change from baseline to 12 weeks dietary supplementation |
| Blood biomarkers of oxidative stress | protein carbonyls, glutathione | Change from baseline to 12 weeks dietary supplementation |
| Blood biomarkers of neurogenesis | BDNF | Change from baseline to 12 weeks dietary supplementation |