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| Name | Class |
|---|---|
| Taipei Medical University | OTHER |
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This randomized, double-blind, placebo-controlled, and parallel clinical study aims to investigate the effectivness of a pumpkin seed extract on blood sugar management in subhealth people.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo group | Placebo Comparator | Placebo capsule, one capsule/day (300 mg/day) for 3 months |
|
| Low dose | Experimental | Pumpkin seed extract capsule, one capsule/day (300 mg/day) for 3 months |
|
| High dose | Experimental | Pumpkin seed extract capsule, two capsules/day (600 mg/day) for 3 months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pumpkin seed extract (Low dose) | Dietary Supplement | Pumpkin seed extract standardized with specific peptides (300 mg/day) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Biochemical analysis | Changes in fasting blodd sugar levels of 60 pariticpants will be analyzed between baseline and week 12. | Baseline up to 12 weeks |
| Biochemical analysis | Changes in glycosylated hemoglobin levels of 60 pariticpants will be analyzed between baseline and week 12. | Baseline up to 12 weeks |
| Biochemical analysis | Changes in insulin levels of 60 pariticpants will be analyzed between baseline and week 12. | Baseline up to 12 weeks |
| Biochemical analysis | Changes in incremental area under the curve for glucose for 60 pariticpants will be analyzed between baseline and week 12. | Baseline up to 12 weeks |
| Hormone analysis | Changes in GLP-1 levels of 60 pariticpants will be analyzed between baseline and week 12. | Baseline up to 12 weeks |
| Hormone analysis | Changes in DPP4 levels of 60 pariticpants will be analyzed between baseline and week 12. | Baseline up to 12 weeks |
| Hormone analysis | Changes in adiponectin levels of 60 pariticpants will be analyzed between baseline and week 12. | Baseline up to 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ming-Shun Wu, MD | Contact | +886-229307930 | mswu@tmu.edu.tw |
| Name | Affiliation | Role |
|---|---|---|
| Ming-Shun Wu, MD | WanFang Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| WanFang Hospital | Recruiting | Taipei | 116 | Taiwan |
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D008659 | Metabolic Diseases |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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Parallel Assignment
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| Pumpkin seed extract (High dose) | Dietary Supplement | Pumpkin seed extract standardized with specific peptides (600 mg/day) |
|
| Placebo | Dietary Supplement | Placeo (300 mg/day) |
|