To evaluate the biomarkers for the prognosis of coronary heart disease, patients with coronary heart disease will be recruited and followed up for at least 2 years.

Patients with cardiovascular disease undergoing coronary angiography will be recruited and prospectively followed up for the incidence of major adverse cardiovascular events (MACE events), including all-cause mortality, cardiovascular mortality, ischemic stroke, heart failure and rehospitalization. Blood and fecal samples will be collected for further analysis. The basic and clinical information will be collected such as socio-demographic, diet, lifestyle, psychological status and medical history. The biomarkers for the incidence of coronary heart disease and the factors contributing to the poor prognosis of coronary heart disease will be investigated based on multi-omics analysis.

Inclusion Criteria:

• Diagnosed as coronary heart disease or with unexplained chest pain needed to undergo coronary angiography.
• Healthy subjects undergoing routine physical examination in the physical examination department and willing to sign informed consent will be recruited as control subjects.

Exclusion Criteria:

• With malignant tumors, infectious diseases and advanced liver diseases.
• Won't sign an inform consent.

Patients with coronary heart diseases undergoing coronary angiography and healthy control subjects undergoing routine physical examination in physical examination department.