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| ID | Type | Description | Link |
|---|---|---|---|
| 1K23HL155506 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
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The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Spontaneous coronary artery dissection (SCAD) group | Other | Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function. |
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| Healthy Control Group | Other | Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Arterial Tonometry | Other | We will measure arterial stiffness using arterial tonometry. |
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| Measure | Description | Time Frame |
|---|---|---|
| Arterial thickness | Measured by carotid ultrasound intimal media thickness reporting in mm | Baseline |
| Arterial stiffness | Measured by carotid ultrasound pulse wave velocity reporting in m/s | Baseline |
| Baroreflex sensitivity | The slope between heart rate and blood pressure at rest and during the Valsalva Maneuver (ms/mmHg) | Baseline |
| Sympathetic response to stress | Blood pressure or muscle sympathetic nerve activity response to sympathoexcitatory stressors (mm/Hg or bursts/min). | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pamela Engrav | Contact | 507-255-6938 | Engrav.Pamela@mayo.edu |
| Name | Affiliation | Role |
|---|---|---|
| Marysia Tweet, MD, MS | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic Rochester | Recruiting | Rochester | Minnesota | 55905 | United States |
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| Echocardiogram | Diagnostic Test | We will collect limited ultrasound images of the heart. |
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| Carotid Ultrasounds | Diagnostic Test | We will perform ultrasound imaging of the carotid artery. |
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| Elastography | Diagnostic Test | We will measure the elastic properties of the arteries using elastography. |
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| Ankle-Brachial Index | Other | We will measure the ankle-brachial index to assess peripheral artery blood flow. |
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| Microneurography with sympathoexcitatory maneuvers | Other | We will measure sympathetic nerve activity at rest and in response to isometric handgrip, mental stress test, cold pressor test, Valsalva maneuvers. |
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| ID | Term |
|---|---|
| C565153 | Coronary Artery Dissection, Spontaneous |
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| ID | Term |
|---|---|
| D004452 | Echocardiography |
| D000092262 | Ultrasonography, Carotid Arteries |
| D054459 | Elasticity Imaging Techniques |
| ID | Term |
|---|---|
| D057791 | Cardiac Imaging Techniques |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D014463 | Ultrasonography |
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
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