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| ID | Type | Description | Link |
|---|---|---|---|
| 1K23HL155506 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
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This study aims to fill knowledge gaps regarding microvascular perfusion and pressor response to stress among patients with history of spontaneous coronary artery dissection (SCAD) using stress contrast echocardiography.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Spontaneous coronary artery dissection (SCAD) | Subject has a history of spontaneous coronary artery dissection (SCAD) |
| |
| Healthy Subjects | Subjects are healthy with no significant medical history |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Stress Echocardiography with Contrast | Procedure | Stress Echocardiography with Contrast will be used to assess heart function and blood flow response to stressors. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Microvascular Function | Microvascular Function will be determined by Microvascular Blood Flow (Liters/Minute). Microvascular Blood Flow will be measured by a stress echocardiogram with contrast. A higher Microvascular Blood Flow indicated better blood flow circulation. | Baseline, immediately after the Stress Echocardiography |
| Change in Blood Pressure | Change is blood pressure will be measured by a stress echocardiogram with contrast (mmHg). | Baseline, immediately after the Stress Echocardiography |
| Change in Heart Rate | Change in heart rate will be measured by a stress echocardiogram with contrast (beats per minute). | Baseline, immediately after the Stress Echocardiography |
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Inclusion Criteria:
Exclusion Criteria:
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Patients will be recruited from the clinic and community.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pamela Engrav | Contact | 507-255-6938 | engrav.pamela@mayo.edu |
| Name | Affiliation | Role |
|---|---|---|
| Marysia Tweet, M.D., M.S. | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic | Recruiting | Rochester | Minnesota | 55905 | United States |
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| ID | Term |
|---|---|
| C565153 | Coronary Artery Dissection, Spontaneous |
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| ID | Term |
|---|---|
| D003287 | Contrast Media |
| ID | Term |
|---|---|
| D064907 | Diagnostic Uses of Chemicals |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D020313 | Specialty Uses of Chemicals |
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