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In the current study, the investigators will compare the effects of low-dose intravenous (i.v.) ketamine versus intrathecal Ketamine added to spinal anesthesia on the time to first request for analgesia and maternal pain scores and overall satisfaction in patients undergoing cesarean section.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intrathecal Ketamine | Active Comparator | Patients will receive intrathecal Ketamine 0.1mg/kg added to bupivacaine and morphine. |
|
| Intravenous ketamine | Active Comparator | Patients will receive IV Ketamine 0.25mg/kg after spinal anesthesia with bupivacaine and morphine. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intrathecal ketamine | Drug | Patients will receive intrathecal Ketamine 0.1mg/kg added to bupivacaine and morphine |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time to the first analgesic request | First Postoperative day |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative pain scores NRS at rest and on movement; (2, 4, 6, 12, and 24 hours) postoperative | first postoperative day |
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Inclusion criteria:
• Pregnant undergoing elective cesarean section
Exclusion Criteria
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Assiut university | Asyut | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28520955 | Background | Abd El-Rahman AM, Mohamed AA, Mohamed SA, Mostafa MAM. Effect of Intrathecally Administered Ketamine, Morphine, and Their Combination Added to Bupivacaine in Patients Undergoing Major Abdominal Cancer Surgery a Randomized, Double-Blind Study. Pain Med. 2018 Mar 1;19(3):561-568. doi: 10.1093/pm/pnx105. |
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| ID | Term |
|---|---|
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| Intravenous ketamine | Drug | Patients will receive IV Ketamine 0.25mg/kg after spinal |
|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |