Laparoscopic Total vs Partial Fundoplication in Patients With Atypical Symptoms of Gastroesophageal Reflux Disease

A Prospective Randomized Trial on Laparoscopic Total vs Partial Fundoplication in Patients With Atypical Symptoms of Gastroesophageal Reflux Disease

One hundred and twenty patients with documented extraesophageal symptoms of gastroesophageal reflux disease were randomized to either undergo floppy Nissen (n= 60) or Toupet fundoplication (n= 60). Symptom scores of extraesophageal symotoms and quality of life were prospectively evaluated. Analysis of the treatment results showed a significant improvement of symptoms in both patient groups.Quality of life improved substantially at short- and long-term follow up in both groups and there were no statistical differences between the groups in this parameter.

Inclusion Criteria:

• extraesophageal symptoms of gastroesophageal reflux disease
• undergoing surgery for gastroesophageal reflux disease
• at least 18 years old

Exclusion Criteria:

• patients under the age of 18 years
• previous anti-reflux surgery, other surgical procedures in the vicinity of the gastroesophageal junction
• major psychiatric illness
• unstable chronic illnesses (such as diabetes)
• inability of the patient to complete the survey.