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glucose hemosatasis, oxidative stress, abnormalities of blood pressures, and high inflammatory status is high presented in lupus patients.
64 lupus prediabetic women will equally distributed to group A (n =32 that will receive laser acupuncture (active) for one month (3 days week) on acupoint number 14 of GV meridian, acupoint number 4 and 11 of large intestine, acupoint number 34 of gall bladder meridian, acupoint number 3 of liver meridian, acupoint number 4, 12, and 9 of conception vessel meridian, acupoint number 40, 36, and 25 of stomach meridian, acupoint number 6 of spleen meridian, and acupoint number 5 of triple energizer meridian, laser will be applied for 1 min on every acupiont) or group B (n =32 this group will receive the same protocol of group A but the points will be sham points)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| laser (active laser) | Active Comparator | 32 lupus prediabetic women will receive laser acupuncture (active laser) for one month (3 days week) on acupoint number 14 of GV meridian, acupoint number 4 and 11 of large intestine, acupoint number 34 of gall bladder meridian, acupoint number 3 of liver meridian, acupoint number 4, 12, and 9 of conception vessel meridian, acupoint number 40, 36, and 25 of stomach meridian, acupoint number 6 of spleen meridian, and acupoint number 5 of triple energizer meridian, laser will be applied for 1 min on every acupiont) |
|
| laser (sham laser) | Sham Comparator | 32 lupus prediabetic women will receive laser acupuncture (sham . i.e power of the device will be zero) for one month (3 days week) on acupoint number 14 of GV meridian, acupoint number 4 and 11 of large intestine, acupoint number 34 of gall bladder meridian, acupoint number 3 of liver meridian, acupoint number 4, 12, and 9 of conception vessel meridian, acupoint number 40, 36, and 25 of stomach meridian, acupoint number 6 of spleen meridian, and acupoint number 5 of triple energizer meridian, laser will be applied for 1 min on every acupiont) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| active laser | Device | 32 lupus prediabetic women will receive laser acupuncture (active laser) for one month (3 days week) on acupoint number 14 of GV meridian, acupoint number 4 and 11 of large intestine, acupoint number 34 of gall bladder meridian, acupoint number 3 of liver meridian, acupoint number 4, 12, and 9 of conception vessel meridian, acupoint number 40, 36, and 25 of stomach meridian, acupoint number 6 of spleen meridian, and acupoint number 5 of triple energizer meridian, laser will be applied for 1 min on every acupiont) |
| Measure | Description | Time Frame |
|---|---|---|
| Malondialdehyde | oxidative stress indicator | It will be measured after 4 weeks of laser application |
| Measure | Description | Time Frame |
|---|---|---|
| systolic blood pressure | manual sphygmomanometer | It will be measured after 4 weeks of laser application |
| diastolic blood pressure | manual sphygmomanometer |
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Inclusion Criteria:
Exclusion Criteria:
based on self-representation of gender identity.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ali Ismail, lecturer | Contact | 02 01005154209 | ali.mohamed@pt.cu.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Ali Ismail, lecturer | Cairo University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo Unoversity | Recruiting | Giza | Egypt |
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| ID | Term |
|---|---|
| D008180 | Lupus Erythematosus, Systemic |
| D011236 | Prediabetic State |
| ID | Term |
|---|---|
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
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|
| sham laser | Device | 32 lupus prediabetic women will receive laser acupuncture (sham laser, i.e power of device will be zero watt) for one month (3 days week) on acupoint number 14 of GV meridian, acupoint number 4 and 11 of large intestine, acupoint number 34 of gall bladder meridian, acupoint number 3 of liver meridian, acupoint number 4, 12, and 9 of conception vessel meridian, acupoint number 40, 36, and 25 of stomach meridian, acupoint number 6 of spleen meridian, and acupoint number 5 of triple energizer meridian, laser will be applied for 1 min on every acupiont) |
|
| It will be measured after 4 weeks of laser application |
| blood glucose | it will be measured in fasting status | It will be measured after 4 weeks of laser application |
| erythrocyte sedimentation rate (at first hour) | it will be measured in serum | It will be measured after 4 weeks of laser application |
| erythrocyte sedimentation rate (at second hour) | it will be measured in serum | It will be measured after 4 weeks of laser application |
| C reactive protein | it will be measured in serum | It will be measured after 4 weeks of laser application |
| adenosine triphosphate | it a measure for energy production | It will be measured after 4 weeks of laser application |
| Nitrate | it will be measured in serum | It will be measured after 4 weeks of laser application |
| Glutathione | it will be measured in serum | It will be measured after 4 weeks of laser application |
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |