CBD, Nutrient Metabolism and Energy Intake

Effects of Acute Cannabidiol (CBD) Supplementation on Nutrient Metabolism and Energy Intake in Healthy Adults

CBD may affect metabolic control and energy intake. However, there is currently little data regarding these specific outcomes in humans. Therefore, this study will investigate whether a single 300 mg dose of CBD can improve metabolic control following a meal and/or reduce energy intake at a subsequent meal. Healthy, adult volunteers will complete two conditions in a crossover design, comparing outcomes following both CBD and placebo supplementation.

Inclusion Criteria:

• Self-report as healthy, male or female, aged 18-50, body mass index ≥18.5 and <30.0

Exclusion Criteria:

• Currently engage in >10 hours moderate or vigorous intensity physical activity per week
• Have consumed CBD or cannabis at all within the past two months
• Have used CBD or cannabis regularly (>2x in a week) within the past four months
• Are suffering from any clinically significant illness
• Have regularly used tobacco within the previous 6 months (> 2/week)
• Currently use any prescription or over-the-counter medications (except for hormonal contraception and simple painkillers)
• Have given a standard blood donation within 30 days of screening
• Are currently pregnant or lactating
• Are allergic/intolerant to any ingredients in food items provided during the study