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CBD may affect metabolic control and energy intake. However, there is currently little data regarding these specific outcomes in humans. Therefore, this study will investigate whether a single 300 mg dose of CBD can improve metabolic control following a meal and/or reduce energy intake at a subsequent meal. Healthy, adult volunteers will complete two conditions in a crossover design, comparing outcomes following both CBD and placebo supplementation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cannabidiol | Experimental | 300 mg CBD (KannaSwiss, Kölliken, Switzerland) dissolved in 1 ml hemp oil. Provided orally in gelatin capsules. |
|
| Placebo | Placebo Comparator | 1 ml hemp oil. Provided orally in gelatin capsules. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acute oral CBD supplementation | Dietary Supplement | 1 ml hemp oil containing 300 mg CBD, within gelatin capsules, ingested orally. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Energy intake | Self-selected energy intake at an ad libitum mixed meal | ~5-30 minutes (time taken to eat a single meal) |
| Postprandial Glycaemia | Plasma glucose response to a mixed meal (plasma glucose concentrations and area under curve) | 3 hours |
| Postprandial Triglyceridaemia | Plasma triglyceride response to a mixed meal (plasma triglyceride concentrations and area under curve) | 3 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Postprandial Insulinaemia | Plasma Insulin response to a mixed meal (plasma insulin concentrations and area under curve) | 3 hours |
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Inclusion Criteria:
• Self-report as healthy, male or female, aged 18-50, body mass index ≥18.5 and <30.0
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Loughborough University | Loughborough | Leicestershire | LE11 3TU | United Kingdom |
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| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D052439 | Lipid Metabolism Disorders |
| D001070 | Appetitive Behavior |
| ID | Term |
|---|---|
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D001522 | Behavior, Animal |
| D001519 | Behavior |
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| Acute oral placebo supplementation | Dietary Supplement | 1 ml hemp oil containing no CBD, within gelatin capsules, ingested orally. |
|