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| Name | Class |
|---|---|
| Bridge Farm Nurseries Limited, Spalding, UK | UNKNOWN |
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CBD may affect metabolic control and energy intake. However, there is currently little data regarding these specific outcomes in humans. Therefore, this study will investigate whether four weeks of supplementation with 60 mg/day CBD affects energy intake at a single meal, and or fasting blood-based markers of appetite regulation and metabolic health. Healthy, adult volunteers will be assigned to placebo or CBD supplementation, in a randomized controlled trial, comparing changes in outcomes across the supplementation period between groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CBD | Experimental | 1 mL hemp oil containing 60 mg/mL CBD, daily. |
|
| Placebo | Placebo Comparator | 1 mL hemp oil containing 0 mg/mL CBD, daily. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cannabidiol (CBD) supplementation | Dietary Supplement | Daily supplementation with 1 ml hemp oil containing 60 mg CBD, applied orally |
|
| Measure | Description | Time Frame |
|---|---|---|
| Energy Intake | Self-selected energy intake at an ad libitum mixed meal | Baseline and after 4 weeks supplementation |
| Measure | Description | Time Frame |
|---|---|---|
| CBD | CBD circulating in plasma | Baseline and after 4 weeks supplementation |
| Liver transaminases | AST and ALT circulating in plasma | Baseline and after 4 weeks supplementation |
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Exclusion Criteria:
Inclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lewis J James, PhD | Contact | 00441509226305 | L.James@lboro.ac.uk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Loughborough University | Recruiting | Loughborough | Leicestershire | LE113TU | United Kingdom |
Individual data for study outcomes will be shared on the Loughborough University Research Repository
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Permanently, after publication of study findings.
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| ID | Term |
|---|---|
| D001070 | Appetitive Behavior |
| ID | Term |
|---|---|
| D001522 | Behavior, Animal |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D002185 | Cannabidiol |
| D019587 | Dietary Supplements |
| ID | Term |
|---|---|
| D002186 | Cannabinoids |
| D013729 | Terpenes |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
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Double-blind
| Placebo supplementation | Dietary Supplement | Daily supplementation with 1 ml hemp oil containing 0 mg CBD, applied orally |
|
| Hormones implicated in appetite regulation | Hormones implicated in appetite regulation (e.g., leptin and ghrelin) circulating in plasma | Baseline and after 4 weeks supplementation |
| Lipoproteins | Lipoproteins (e.g., total cholesterol, HDL-C and LDL-C) circulating in plasma | Baseline and after 4 weeks supplementation |
| Glucose | Glucose circulating in plasma | Baseline and after 4 weeks supplementation |
| Triglycerides | Triglycerides circulating in plasma | Baseline and after 4 weeks supplementation |
| Insulin | Insulin circulating in plasma | Baseline and after 4 weeks supplementation |
| Subjective appetite (hunger, fullness, desire to eat) | Measured using pen and paper scales (scored 'not at all' [0 mm] to 'extremely' [100 mm]) | Baseline and after 4 weeks supplementation |
| self-reported adverse events | Adverse events reported in diary by participants | During 4 weeks supplementation |
| D005502 |
| Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |