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| ID | Type | Description | Link |
|---|---|---|---|
| ID-RCB | Other Identifier | 2021 - A03232-39 |
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Out of 30,000 new cases per year in France, 30% of epileptic patients are drug-resistant. Neurosurgery, which consists in resecting the epileptogenic zone, is the only chance of cure. In the case of temporal epilepsy of the language-dominant hemisphere (TLE), this procedure presents a high risk of increasing cognitive difficulties and may even be contraindicated for this reason alone. The difficulties found are impairments in lexical access (anomia) and verbal memory and affect more than 60% of patients . Preoperative cognitive rehabilitation could influence brain plasticity mechanisms but there are currently no recommendations on this topic. In this context, the investigators have developed a speech rehabilitation procedure specific to the needs of ELTPR patients. They rely on cognitive hypotheses explaining the disorders but also on models of rehabilitation-induced neural plasticity likely to improve cognitive reserve before surgery. The investigators hypothesize that preoperative cognitive language rehabilitation in ELTPR patients may decrease surgical risk and improve postoperative language prognosis.
The primary objective is to demonstrate the protective efficacy of preoperative speech rehabilitation on language performance postoperatively.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Other | Patients will have speech therapy assessment in addition to standard care. |
|
| Experimental | Experimental | Patients will have speech therapy assessment and intensive speech rehabilitation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Speech therapy | Procedure | Patients will connect on an interface to pratice speech therapy |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Effect of rehabilitation on immediate postoperative performances | Number of images quoted | Day 7 after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Impact of rehabilitation on long-term postoperative performance | Number of images quoted | 6 months after surgery |
| Impact of rehabilitation on immediate on standardized language tests | % of correct answers of language tests |
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Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Veronique Sabadell | Contact | 0491385298 | 33 | veronique.sabadell@ap-hm.fr |
| Name | Affiliation | Role |
|---|---|---|
| Francois CREMIEUX | AP-HM | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service EFSN - Hôpital Pellegrin | Recruiting | Bordeaux | France |
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| Speech therapy assessment |
| Procedure |
Patients will be followed by an speech therapist |
|
| Day 7 after surgery |
| Impact of rehabilitation on long-term postoperative performance on standardized language tests | % of correct answers of language tests | 6 months after surgery |
| Impact of preoperative rehabilitation on verbal memory | Verbal memory task | Day 7 after surgery |
| Impact of preoperative rehabilitation on verbal memory | Verbal memory task | 6 months after surgery |
| Lexical fluency | Lexical evocation tests limited to 2 minutes according to a formal criterion or an imposed categorical criterion | Day 7 after surgery |
| Lexical fluency | lexical evocation tests limited to 2 minutes according to a formal criterion or an imposed categorical criterion | 6 months after surgery |
| Denomination of control lists | Number of words quoted | Day 7 after surgery |
| Denomination of control lists | Number of words quoted | 6 months after surgery |
| Self-reported perception of anomia | Use of an ad-hoc scale graduated from 0 (no complaint) to 10 (maximum complaint) | Day 7 after surgery |
| Self-reported perception of anomia | Ad-hoc scale graduated from 0 (no complaint) to 10 (maximum complaint) | 6 months after surgery |
| Evaluation of Quality of life | Quality Of Life in Epilepsy Inventory (QOLIE-31) (0 meaning better outcome, highest score meaning worse outcome) | Day 7 after surgery |
| Evaluation of Quality of life | Quality Of Life in Epilepsy Inventory (QOLIE-31) (0 meaning better outcome, highest score meaning worse outcome) | 6 months after surgery |
| Impact of pre-operative rehabilitation on the number of post-operative rehabilitation sessions | Number of speech therapy sessions performed postoperatively | 6 months after surgery |
| Service de Neurologie de l'Epilepsie - CHU Grenoble-Alpes | Recruiting | Grenoble | France |
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| Département de Neurophysiologie Clinique - Hôpital Roger Salengro - CHU Lille | Recruiting | Lille | France |
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| Hôpital Neurologique Pierre Wertheimer- Service de Neurologie Fonctionnelle et Epileptologie - Hospices Civils Lyon | Not yet recruiting | Lyon | France |
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| Service Epilptologie et Rythmologie Cérébrale | Recruiting | Marseille | France |
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| Service de Neurologie - Hôpital central -CHU Nancy | Not yet recruiting | Nancy | France |
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| Département de Neurologie - Hôpital de la Pitié-Salpêtrière - APHP | Not yet recruiting | Paris | France |
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| Service de Neurochirurgie -GHU Sainte-Anne | Not yet recruiting | Paris | France |
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| Service de Neurologie - Fondation ophtalmologique de Rothschild - Fondation Rothschild | Recruiting | Paris | France |
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| Service de Neurologie - CHU de Rennes | Not yet recruiting | Rennes | France |
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| Service de Neurologie - Hôpitaux Universitaires, Hôpital de Hautepierre | Recruiting | Strasbourg | France |
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| Explorations Neurophysiologiques, Pôle des Neurosciences - Hôpital Pierre Paul Riquet, Purpan | Not yet recruiting | Toulouse | France |
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| ID | Term |
|---|---|
| D004827 | Epilepsy |
| D000849 | Anomia |
| D004833 | Epilepsy, Temporal Lobe |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D004828 | Epilepsies, Partial |
| D000073376 | Epileptic Syndromes |
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| ID | Term |
|---|---|
| D013070 | Speech Therapy |
| ID | Term |
|---|---|
| D012049 | Rehabilitation of Speech and Language Disorders |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
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