Clinical Study to Evaluate the Possible Efficacy and Safety of L- Carnitine and Sildenafil in Children Having Beta Thalassemia With Increased Tricuspid Regurgitant Jet Velocity

Clinical Study to Evaluate the Possible Efficacy and Safety of L- Carnitine and Sildenafil in Children Having Beta Thalassemia With Increased Tricuspid Regurgitant Jet Velocity

This study aims to investigate the possible efficacy and safety of L_Carnitine and Sildenafil on patient with Beta thalassemia complicated with increased Tricuspid Regurgitant Jet Velocity

Inclusion Criteria:

• Children with Beta thalassemia major who have increased TRJV more than 2.5m/s.
• Children age from 6-18 years

Exclusion Criteria:

• Others hemolytic anemia

  • Young age before 6 years of age
  • Allergy to Sildenafil or L-carnitine
  • Patient with documented causes of pulmonary hypertension rather than caused by Beta thalassemia.
  • Hepatic dysfunction: serum Alanine Aminotransferase (ALT) 3X.
  • Renal dysfunction: Creatinine level greater than or equal to 1.2 mg/dl.