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This study aims to investigate the possible efficacy and safety of L_Carnitine and Sildenafil on patient with Beta thalassemia complicated with increased Tricuspid Regurgitant Jet Velocity
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 | Active Comparator | n=22): Patients will receive traditional treatment and L- carnitine 50mg/kg/day orally (maximum dose 3g per day) |
|
| Group 2 | Active Comparator | n=22): Patients will receive traditional treatment and Sildenafil 0.25mg/kg/dose every 6 h orally (maximum dose 60 mg per day) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| L_carnitine | Drug | l-carnitine stabilizes red blood cell membranes and thus improves the anemic state[](streamdown:incomplete-link) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cardiopulmonary functions | change in the studied cardiopulmonary functions at the baseline and 3 months after intervention | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Biochemical parameters | Changes in Vascular Endothelial Growth Factor level (VEGF) at baseline and 3 months after the intervention | 3 months |
| Biochemical parameters | Changes in Nitric oxide level (NO) at the baseline and 3 months after the intervention |
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Inclusion Criteria:
Exclusion Criteria:
Others hemolytic anemia
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mostafa Zaki Zedan, Bsc of pharmaceutical science | Contact | +0201554676330 | mostaf150776@pharm.tanta.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Sahar Kamal Hegazy, Professor | Tanta University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tanta University Hospital | Recruiting | Tanta | Gharbia Governorate | 31511 | Egypt |
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| Sildenafil | Drug | selective and potent inhibitor of cGMP-specific phosphodiesterase 5 (PDE5), which promotes smooth muscle relaxation in lung vasculature, has been used successfully in the treatment of primary and secondary PH. |
|
| 3 months |
| Biochemical parameters | Changes in ferritin serum level at the baseline and 3 months after the intervention | 3 months |
| ID | Term |
|---|---|
| D000068677 | Sildenafil Citrate |
| ID | Term |
|---|---|
| D013449 | Sulfonamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D013450 | Sulfones |
| D013457 | Sulfur Compounds |
| D010879 | Piperazines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D011687 | Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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