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| ID | Type | Description | Link |
|---|---|---|---|
| 3342 |
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The purpose of this study is determination of the efficacy of combination of hydroxyurea with L-carnitine or magnesium in improving hematologic parameters and cardiac status in patients with β-thalassemia intermedia in comparison with hydroxyurea alone .
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Hydroxyurea |
|
| 2 | Active Comparator | L-carnitine and hydroxyurea |
|
| 4 | Active Comparator | L-carnitine , magnesium chloride and hydroxyurea |
|
| 3 | Active Comparator | magnesium chloride and hydroxyurea |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| hydroxyurea | Drug | Hydroxyurea (500 mg capsules) was administered in a single dose at a mean of 10/mg/kg/day (range8-12mg/kg/day). |
|
| Measure | Description | Time Frame |
|---|---|---|
| Hematologic Parameters | monthly |
| Measure | Description | Time Frame |
|---|---|---|
| echocardiographic parameters | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mehran Karimi, Full Professor | Hematology Research Center of Shiraz University of Medical Sciences | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hematology Research Center of Shiraz University of Medical Sciences | Shiraz | Fars | Iran |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36637054 | Derived | Foong WC, Loh CK, Ho JJ, Lau DS. Foetal haemoglobin inducers for reducing blood transfusion in non-transfusion-dependent beta-thalassaemias. Cochrane Database Syst Rev. 2023 Jan 13;1(1):CD013767. doi: 10.1002/14651858.CD013767.pub2. |
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| L-carnitine and hydroxyurea | Drug | Hydroxyurea (500 mg capsules) was administered in a single dose at a mean of 10/mg/kg/day (range8-12mg/kg/day). L-carnitine (Minoo, Iran, 250 mg tablets) was administered in divided doses (50mg/kg/day). |
|
| hydroxyurea and magnesium chloride | Drug | Hydroxyurea (500 mg capsules) was administered in a single dose at a mean of 10/mg/kg/day (range8-12mg/kg/day). Magnesium chloride powder ( tabib tajhiz nik, Iran) was formulated into suspension; each ml containing 1meq magnesium chloride. It was administered in divided doses at 0.6meq/kg/day. |
|
| hydroxyurea,L-carnitine and magnesium chloride | Drug | Hydroxyurea (500 mg capsules) was administered in a single dose at a mean of 10/mg/kg/day (range8-12mg/kg/day). L-carnitine (Minoo, Iran, 250 mg tablets) was administered in divided doses (50mg/kg/day). Magnesium chloride powder ( tabib tajhiz nik, Iran) was formulated into suspension; each ml containing 1meq magnesium chloride. It was administered in divided doses at 0.6meq/kg/day |
|
| ID | Term |
|---|---|
| D006918 | Hydroxyurea |
| D002331 | Carnitine |
| D015636 | Magnesium Chloride |
| ID | Term |
|---|---|
| D014508 | Urea |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D050337 | Trimethyl Ammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017616 | Magnesium Compounds |
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