Combination Therapy of Hydroxyurea With L-Carnitine and Magnesium Chloride in Thalassemia Intermedia

The Effect of Combination Therapy of Hydroxyurea With L- Carnitine and Magnesium Chloride on he-Matologic Parameters and Cardiac Function of β-Thalassemia Intermedia Patients.

The purpose of this study is determination of the efficacy of combination of hydroxyurea with L-carnitine or magnesium in improving hematologic parameters and cardiac status in patients with β-thalassemia intermedia in comparison with hydroxyurea alone .

Inclusion Criteria:

• Beta thalassemia intermedia patients with mean hemoglobin level >= 7gr/dl, need to blood transfusion with more than 6 months interval or no need to blood transfusion

Exclusion Criteria:

• Hypothyroidism
• Hypoparathyroidism
• Diabetes mellitus
• Hepatitis B and C
• Positive tests for human immunodeficiency virus
• Any cardiac symptoms or receiving drug for cardiac disease
• Presence of other hemoglobinopathies except thalassemia intermedia and pregnant or lactating womens