Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study aims to investigate the possible efficacy and safety of L-Arginine in children having Sickle Cell Disease with increased Tricuspid Regurgitant Jet Velocity
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group | No Intervention | this group will include 25 patients who will receive their standard therapy for 3 months | |
| L-Arginine group | Active Comparator | this group will include 25 patients who will receive L-Arginine 0.1-0.2 g/kg/day and their standard therapy for 3 months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| L-Arginine | Drug | L-Arginine 1000 mg free form, rapid release capsules |
|
| Measure | Description | Time Frame |
|---|---|---|
| change in tricuspid regurgitant jet velocity (TRJV) detected by Color Doppler Echocardiography | patients will undergo Color Doppler Echocardiography to assess tricuspid regurgitant jet velocity (TRJV) at baseline and after 3 months | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| change in serum level of N-terminal pro b-type natriuretic peptide (NT-pro-BNP) | Blood samples will be collected at baseline and after 3 months | 3 months |
| change in serum level of L-Arginine | Blood samples will be collected at baseline and after 3 months |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| dalia A gomaa | Tanta University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tanta university | Tanta | Other (Non U.s.) | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40526198 | Derived | Gomaa DA, El-Haggar SM, El-Shanshory MR, El-Razaky O, El-Afify DR. Clinical Study to Evaluate the Possible Efficacy and Safety of L-Arginine in Children with Sickle Cell Disease and Increased Tricuspid Regurgitant Jet Velocity: a Randomized Controlled Trial. Paediatr Drugs. 2025 Sep;27(5):605-618. doi: 10.1007/s40272-025-00701-w. Epub 2025 Jun 17. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D000755 | Anemia, Sickle Cell |
| ID | Term |
|---|---|
| D000745 | Anemia, Hemolytic, Congenital |
| D000743 | Anemia, Hemolytic |
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D001120 | Arginine |
| ID | Term |
|---|---|
| D024361 | Amino Acids, Basic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000599 | Amino Acids, Diamino |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| 3 months |
| change in serum level of Asymmetric Dimethyl Arginine (ADMA) | Blood samples will be collected at baseline and after 3 months | 3 months |
| change in serum level of Nitric Oxide | Blood samples will be collected at baseline and after 3 months | 3 months |
| D006425 |
| Hemic and Lymphatic Diseases |
| D006453 | Hemoglobinopathies |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D000601 | Amino Acids, Essential |