The Relation Between MiR-125b-5p and Staging of Endometriosis

Estimation of Plasma Levels of MicroRNA 125b-5p and Transvaginal Ultrasonography May Spare Laparoscopy for Staging of Endometriosis

78 endometriosis patients presented with infertility were clinically examined and the diagnosis was assured by US imaging. The study also included 11 control fertile women free of gynecological problems as a control for lab tests. Patients and controls gave blood samples for lab investigations. All patients underwent diagnostic abdominal laparoscopy under general anesthesia for disease staging. Quantitative determination of expression levels of genes of microRNA-125b-5p and 203a was conducted using qRT-PCR.

Inclusion Criteria:

• Patients who presented clinical pictures suggestive of EM disease

Exclusion Criteria:

• Patients with previous pelvic or abdominal surgery that may hinder the laparoscopic examination,
• patients who were suspicious of having malignancy elsewhere in the body region,
• pregnant women,
• patients who had diabetes mellitus,
• body mass index (BMI) of >30 kg/m2, coagulopathies, and autoimmune disorders.