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OBJECTIVES :
Study Design:
Case control study. sample size: 200
METHODOLOGY :
1 Investigator will take Both blood and tissue samples used to study them. 2. Investigator will take approximately 3 ml of blood which will be used from the blood sample collected for routine preoperative tests (Surgical profile) before their planned surgery.
3.Small tissue samples will be taken from the tissue which is surgically excised as a part of treatment.
4. It will include tissue from inner lining of uterus (endometrium) in all participants and from excised endometriosis tissue in patients with endometriosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 100 women undergoing surgery (laparoscopy / laparotomy) with presumed diagnosis of endometriosis | Experimental |
|
|
| 100 women undergoing surgery for gynaecological disorders other than endometriosis or adenomyosis | No Intervention | . We Will take Both blood and tissue samples used to study them. 2. We Will take approximately 3 ml of blood which will be used from the blood sample collected for routine preoperative tests (Surgical profile) before their planned surgery. 3.Small tissue samples will be taken from the tissue which is surgically excised as a part of treatment. 4. It will include tissue from inner lining of uterus (endometrium) in all participants and from excised endometriosis tissue in patients with endometriosis. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 100 women undergoing surgery (laparoscopy / laparotomy) with presumed diagnosis of endometriosis | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| 2. To understand the function of candidate predictive miRNAs for endometriosis by investigating their downstream targets and associated biological pathways | ROC curve analysis is to estimate the sensitivity and specificity of miRNA expression levels to establish them as biomarkers for endometriosis. | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| To investigate the expression pattern of miRNAs and their downstream targets in endometrial tissues (samples of normal adult endometrium and ectopic and eutopic endometrium of patients with endometriosis) | Western Blot and immunohistochemical analysis (IHC) for expression analysis.. | 3 years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Shraddha Ramchandani | Asian Institute of Gastroenterology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shraddha Ramchandani | Hyderabad | Telanagana | 500082 | India |
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case control study 100 women undergoing surgery (laparoscopy / laparotomy) with presumed diagnosis of endometriosis and 100 women undergoing surgery for gynaecological disorders
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|
| women with intraoperative and / or histopathology findings suggestive of endometriosis | Procedure |
|
|
| ID | Term |
|---|---|
| D004715 | Endometriosis |
| D003967 | Diarrhea |
| D008599 | Menstruation Disturbances |
| D008796 | Metrorrhagia |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010335 | Pathologic Processes |
| D014592 | Uterine Hemorrhage |
| D014591 | Uterine Diseases |
| D006470 | Hemorrhage |
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| ID | Term |
|---|---|
| D010535 | Laparoscopy |
| D007813 | Laparotomy |
| ID | Term |
|---|---|
| D004724 | Endoscopy |
| D003949 | Diagnostic Techniques, Surgical |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D019060 | Minimally Invasive Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
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