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This study was a single-center, non-randomized, parallel-group design clinical trial, and each group was assigned a 1:1 ratio with or without hyperlipidemia. Both groups underwent periodontal non-surgical treatment, and blood and gingival crevicular fluid were collected before surgery, 1 month and 3 months after surgery for the detection of MCP-1, IL-8, oxLDL, TNF-α, TG, LDL-C, HDL-C.
This study was a single-center, non-randomized, parallel-group design clinical trial, and each group was assigned a 1:1 ratio with or without hyperlipidemia. Both groups underwent periodontal non-surgical treatment, and blood and gingival crevicular fluid were collected before surgery, 1 month and 3 months after surgery for the detection of MCP-1, IL-8, oxLDL, TNF-α, TG, LDL-C, HDL-C.MCP-1, IL-8, oxLDL, TNF-α will be tested for concentration using ELISA.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HP | Chronic periodontitis (stage III/IV) patients with hyperlipidemia |
| |
| CP | Chronic periodontitis(stage III/IV) patients without hyperlipidemia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| non-surgical periodontal therapy | Procedure | supragingival scaling,subgingival scaling |
|
| Measure | Description | Time Frame |
|---|---|---|
| monocyte chemotactic protein-1，MCP-1 | Concentration of MCP-1 in gingival crevicular fluids | Before surgery |
| monocyte chemotactic protein-1，MCP-1 | Concentration of MCP-1 in gingival crevicular fluids | 1 month after surgery |
| monocyte chemotactic protein-1，MCP-1 | Concentration of MCP-1 in gingival crevicular fluids | 3 months after surgery |
| oxidized low-density lipoprotein cholesterol, oxLDL | Concentration of oxLDL in gingival crevicular fluids and serum | Before surgery |
| oxidized low-density lipoprotein cholesterol, oxLDL | Concentration of oxLDL in gingival crevicular fluids and serum | 1 month after surgery |
| oxidized low-density lipoprotein cholesterol, oxLDL | Concentration of oxLDL in gingival crevicular fluids and serum | 3 months after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| interleukin-8，IL-8 | Concentration of IL-8 in gingival crevicular fluids | Before surgery |
| interleukin-8，IL-8 | Concentration of IL-8 in gingival crevicular fluids |
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Inclusion Criteria:
Exclusion Criteria:
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People in Southern China
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yanmin Wu | Contact | +86 137 5711 9560 | wuyanmin@zju.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 2nd Affiliated Hospital, School of Medicine, Zhejiang University | Recruiting | Hangzhou | Zhejiang | 310000 | China |
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serum
| 1 month after surgery |
| interleukin-8，IL-8 | Concentration of IL-8 in gingival crevicular fluids | 3 months after surgery |
| triglycerides，TG | Concentration of TG in serum | Before surgery |
| triglycerides，TG | Concentration of TG in serum | 1 month after surgery |
| triglycerides，TG | Concentration of TG in serum | 3 months after surgery |
| low-density lipoprotein cholesterol，LDL-C | Concentration of LDL-C in serum | Before surgery |
| low-density lipoprotein cholesterol，LDL-C | Concentration of LDL-C in serum | 1 month after surgery |
| low-density lipoprotein cholesterol，LDL-C | Concentration of LDL-C in serum | 3 months after surgery |
| high-density lipoprotein cholesterol，HDL-C | Concentration of HDL-C in serum | Before surgery |
| high-density lipoprotein cholesterol，HDL-C | Concentration of HDL-C in serum | 1 month after surgery |
| high-density lipoprotein cholesterol，HDL-C | Concentration of HDL-C in serum | 3 months after surgery |
| probing depth，PD | The distance (mm) from the bottom of the periodontal pocket to the gingival margin was measured with a periodontal probe (UNC-15, Hu-Friedy, Chicago, IL) parallel to the long axis of the tooth. The mesial, median and distal 6 sites of the labial (buccal) and lingual surfaces were recorded for each tooth. | Before surgery |
| probing depth，PD | The distance (mm) from the bottom of the periodontal pocket to the gingival margin was measured with a periodontal probe (UNC-15, Hu-Friedy, Chicago, IL) parallel to the long axis of the tooth. The mesial, median and distal 6 sites of the labial (buccal) and lingual surfaces were recorded for each tooth. | 1 month after surgery |
| probing depth，PD | The distance (mm) from the bottom of the periodontal pocket to the gingival margin was measured with a periodontal probe (UNC-15, Hu-Friedy, Chicago, IL) parallel to the long axis of the tooth. The mesial, median and distal 6 sites of the labial (buccal) and lingual surfaces were recorded for each tooth. | 3 months after surgery |
| clinical attachment level，CAL | The periodontal probe measures the distance (mm) from the bottom of the gingival sulcus or the bottom of the periodontal pocket to the cementoenamel boundary. The mesial, median and distal 6 points of the labial (buccal) and lingual surfaces were recorded for each tooth. | Before surgery |
| clinical attachment level，CAL | The periodontal probe measures the distance (mm) from the bottom of the gingival sulcus or the bottom of the periodontal pocket to the cementoenamel boundary. The mesial, median and distal 6 points of the labial (buccal) and lingual surfaces were recorded for each tooth. | 1 month after surgery |
| clinical attachment level，CAL | The periodontal probe measures the distance (mm) from the bottom of the gingival sulcus or the bottom of the periodontal pocket to the cementoenamel boundary. The mesial, median and distal 6 points of the labial (buccal) and lingual surfaces were recorded for each tooth. | 3 months after surgery |
| percentage of bleeding on probing，BOP% | Gently probe to the bottom of the bag or gingival sulcus, take out the probe and observe for 10-15 seconds to see if there is any bleeding. The mesial, median and distal 6 sites of the labial (buccal) and lingual surfaces were recorded for each tooth. Calculate the percentage of bleeding sites. | Before surgery |
| percentage of bleeding on probing，BOP% | Gently probe to the bottom of the bag or gingival sulcus, take out the probe and observe for 10-15 seconds to see if there is any bleeding. The mesial, median and distal 6 sites of the labial (buccal) and lingual surfaces were recorded for each tooth. Calculate the percentage of bleeding sites. | 1 month after surgery |
| percentage of bleeding on probing，BOP% | Gently probe to the bottom of the bag or gingival sulcus, take out the probe and observe for 10-15 seconds to see if there is any bleeding. The mesial, median and distal 6 sites of the labial (buccal) and lingual surfaces were recorded for each tooth. Calculate the percentage of bleeding sites. | 3 months after surgery |
| ID | Term |
|---|---|
| D006949 | Hyperlipidemias |
| D010518 | Periodontitis |
| ID | Term |
|---|---|
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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