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This study intends to study the optimal dose induced by etomidate in outpatients undergoing painless hysteroscopic surgery. At present, the dosage in the user manual is 0.1-0.3mg/kg. In clinical use, it is found that 0.1mg/kg often fails to achieve sedative effect, and 0.3mg/kg is prone to muscle twitching. Therefore, three groups of doses of 0.15mg/kg, 0.2mg/kg and 0.25mg/kg are set. It is hoped that this study will provide a basis for clinical evaluation of etomidate in anesthesia induction of hysteroscopic surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Eto 0.15mg/kg | Experimental | Etomidate 0.15mg/kg for anesthesia induction |
|
| Eto 0.2mg/kg | Experimental | Etomidate 0.2mg/kg for anesthesia induction |
|
| Eto 0.25mg/kg | Experimental | Etomidate 0.25mg/kg for anesthesia induction |
|
| Propofol 2mg/kg | Active Comparator | propofol 2mg/kg for anesthesia induction |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| etomidate | Drug | use etomidate for anesthesia induction in hysteroscopic surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mean Arterial Pressure | Mean value of Mean Arterial Pressures | Change in Mean Arterial Pressure(MAP) in mm of Hg from baseline value every 5 minutes for 30 minutes |
| Heart rate per minute | Mean of Heart rate per minute at above mentioned time intervals was measured and any study drug causing bradycardia | Change in Heart rate per minute from baseline value every five minutes for 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Myoclonic movements | % of cases with Myoclonic movements | 60 seconds after injection of study drug |
| Post Operative Nausea and Vomiting | % of cases with any treatment for Post Operative Nausea and Vomiting |
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Inclusion Criteria:
Patients to undergo hysteroscopic surgery
Exclusion Criteria:
Hemo-dynamically unstable patients Allergic to egg protein Patients with epilepsy
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| ID | Term |
|---|---|
| D005045 | Etomidate |
| D015742 | Propofol |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| propofol | Drug | use propofol for anesthesia induction in hysteroscopic surgery |
|
| Throughout entire study estimated to take 1 month to complete |
| any oxygen saturation event below 85% by pulse oximetry | % of cases with any oxygen saturation event below 85% by pulse oximetry | Throughout entire study estimated to take 1 month to complet |
| D010636 |
| Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |