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To explore the feasibility of different doses of etomidate admixed with propofol in induced abortion: a randomized, double blind controlled trial.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Experimental | In group A, propofol (1%) was mixed with etomidate in the ration of 1:1 (volume). The mixture will be injected continuously until the eyelash reflex disappears. During the operation, supplementary mixture will be administered if the patient has spontaneous movement that hampered the conduct of the procedure. |
|
| Group B | Experimental | In group B, propofol (1%) was mixed with etomidate in the ration of 7:5 (volume). The mixture will be injected continuously until the eyelash reflex disappears. During the operation, supplementary mixture will be administered if the patient has spontaneous movement that hampered the conduct of the procedure. |
|
| Group C | Experimental | In group C, propofol (1%) will be injected continuously until the eyelash reflex disappears. During the operation, supplementary propofol will be administered if the patient has spontaneous movement that hampered the conduct of the procedure. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| pentazocine | Drug | Every patient enrolled in the study will be given 15 mg pentazocine before induction. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate | Heart rate will be recorded immediately when the patient arrived at the operating room, 2 min, 4 min, 6 min, 8 min and 10 minutes after the the injection of propofol or mixture of propofol and etomidate. | From baseline (before the injection of propofol or mixture of propofol and etomidate) to 10 min after the injection |
| Blood pressure | Blood pressure will be recorded immediately when the patient arrived at the operating room, 2 min, 4 min, 6 min, 8 min and 10 minutes after the the injection of propofol or mixture of propofol and etomidate. | From baseline (before the injection of propofol or mixture of propofol and etomidate) to 10 min after the injection |
| Pulse oxygen saturation | Pulse oxygen saturation will be recorded immediately when the patient arrived at the operating room, 2 min, 4 min, 6 min, 8 min and 10 minutes after the the injection of propofol or mixture of propofol and etomidate. | From baseline (before the injection of propofol or mixture of propofol and etomidate) to 10 min after the injection |
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy of anesthesia | The following point-in-time will be recorded to calculated the period from the injection of propofol or mixture of propofol and etomidate: disappearance of eyelash reflex, injection of supplementary propofol or mixture of propofol and etomidate, awaking, obeying commands, discharge. Anesthesia time was defined as the period from disappearance of eyelash reflex to awaking. | from baseline to discharge from the hospital, expected to no more than 1 hour |
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Inclusion Criteria:
Exclusion Criteria:
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| propofol | Drug |
|
| Etomidate | Drug |
|
| Dose of propofol or mixture of propofol and etomidate | from the injection of propofol or mixture of propofol and etomidate to the last supplement of hypnotic agents, expected to be no more than 5 min |
| Use of specific medications | from the injection of propofol or mixture of propofol and etomidte to discharge from the hospital, expected to no more than 1 hour |
| Aldrete score | 10 min after the opration |
| Verbal rating scales of uterine contraction | Verbal rating scales of uterine contraction should be recorded at 5 min, 15 min after the operation and before discharge from the hospital | from 5 min after the operation to discharge from the hospital, expected to be no more than 1 hour |
| Satisfaction degree of the patient, the surgeon and the anesthetist | Satisfaction degree will be rated as excellent, good and poor based on a scale of 1 to 10. Excellent is 8 to 10, good is 5 to 7 and poor is 1 to 4. | 10 min before discharge from the hospital |
| ID | Term |
|---|---|
| D010423 | Pentazocine |
| D015742 | Propofol |
| D005045 | Etomidate |
| ID | Term |
|---|---|
| D001575 | Benzomorphans |
| D009019 | Morphinans |
| D053610 | Opiate Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D010616 | Phenanthrenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D011083 | Polycyclic Compounds |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
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