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To compare the effect of propofol and etomidate in hysteroscopy on postoperative sedation and cognitive function in elderly patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group E | Experimental | Etomidate/remifentanil group. Patients in group E will be given etomidate and remifentanil during the operation, the speeds are 10~15 μg/kg/min and 0.2~0.4 μg/kg/min, respectively. |
|
| Group P | Experimental | Propofol/remifentanil group. Patients in group P will be given propofol and remifentanil during the operation, the speeds are 50~75 μg/kg/min and 0.2~0.4 μg/kg/min, respectively. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Etomidate | Drug |
|
| |
| Propofol |
| Measure | Description | Time Frame |
|---|---|---|
| Heart rate | heart rate will be recorded immediately after the entrance to the operating room, at the beginning of induction, 2.5 min, 5 min, 7.5 min, 10 min, 15 min, 20 min, 25 min and 30 min after the beginning of induction, 5 min, 10 min, 15 min, 20 min, 30 min, 45 min and 60 min after the operation. | Immediately after the entrance to the operating room until until 60 minutes after the operation |
| Mean arterial pressure | Mean arterial pressure will be recorded immediately after the entrance to the operating room, at the beginning of induction, 2.5 min, 5 min, 7.5 min, 10 min, 15 min, 20 min, 25 min and 30 min after the beginning of induction, 5 min, 10 min, 15 min, 20 min, 30 min, 45 min and 60 min after the operation. | Immediately after the entrance to the operating room until until 60 minutes after the operation |
| Pulse oxygen saturation | Pulse oxygen saturation will be recorded immediately after the entrance to the operating room, at the beginning of induction, 2.5 min, 5 min, 7.5 min, 10 min, 15 min, 20 min, 25 min and 30 min after the beginning of induction, 5 min, 10 min, 15 min, 20 min, 30 min, 45 min and 60 min after the operation. | Immediately after the entrance to the operating room until until 60 minutes after the operation |
| Respiratory rate | Respiratory rate will be recorded immediately after the entrance to the operating room, at the beginning of induction, 2.5 min, 5 min, 7.5 min, 10 min, 15 min, 20 min, 25 min and 30 min after the beginning of induction, 5 min, 10 min, 15 min, 20 min, 30 min, 45 min and 60 min after the operation. | Immediately after the entrance to the operating room until until 60 minutes after the operation |
| Narcotrend index | Narcotrend index will be recorded immediately after the entance to the operating room, at the beginning of induction, 2.5 min, 5 min, 7.5 min, 10 min, 15 min, 20 min, 25 min and 30 min after the beginning of induction, 5 min, 10 min, 15 min, 20 min, 30 min, 45 min and 60 min after the operation. |
| Measure | Description | Time Frame |
|---|---|---|
| Cerebral injury parameters | 2 ml blood will be collected immediately after the entrance to the operating room and 60 min after the operation, then SB-100 protein and neuron-specific enolase will be tested by enzyme-linked immunosorbent assay. | Immediately after the entrance to the operating room until until 60 minutes after the operation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wenying Song | Contact | +86-13609245447 | swysong2010@126.com |
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| Drug |
|
| Remifentanil | Drug | During anesthesia maintenance, all patients will be given remifentanil at the speed of 0.2~0.4 μg/kg/min. |
|
| Anesthesia induction | Drug | For all patients, the induction protocol is midazolam 0.1 mg/kg, sufentanil 0.3 μg/kg, cisatracurium 0.15 mg/kg. |
|
| Immediately after the entrance to the operating room until until 60 minutes after the operation |
| Length of stay |
| from the date of admission to the day of discharge, expected to 3 days |
| Score of Minimum Mental State Examination | Score of Minimum Mental State Examination will be examined in preoperative visit, 10 minutes, 45 minutes after the operation | 1 day before the operation to 45 minutes after the operation |
| Verbal Fluency test | Verbal Fluency test will be examined in preoperative visit and 60 minutes after the operation | 1 day before the operation to 60 minutes after the operation |
| ID | Term |
|---|---|
| D005045 | Etomidate |
| D015742 | Propofol |
| D000077208 | Remifentanil |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D011422 | Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D010880 | Piperidines |
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