Treatment of Patients With Bone Tissue Defects Using Mesenchymal Stem Cells Enriched by Extracellular Vesicles

Treatment of Patients With Segmental Bone Tissue Defects Using Mesenchymal Stem Cells Enriched by Extracellular Vesicles

Treatment of patients with segmental bone tissue defects using mesenchymal stem cells enriched by extracellular vesicles

The aims of the project are to develop a technology for obtaining mesenchymal stem cells extracellular vesicles; to develop biomedical cell product based on mesenchymal stem cells enriched with own extracellular vesicles; to conduct the clinical trials of the biomedical cell product in the treatment of patients with segmental bone tissue defects

Inclusion Criteria:

• age 18-50 years;
• non-union fractures of the tubular bones of the upper limb;
• segmental defects of the bone tissue of the tubular bones of the upper limbs;
• absence of severe comorbidity worsening the patient's prognosis.

Exclusion Criteria:

• pregnancy;
• acute inflammatory processes;
• viral hepatitis B and C, HIV infection, syphilis and other viral and bacterial infections;
• autoimmune diseases;
• allergic reactions in the acute stage, established hypersensitivity to any component of the biomedical cell product;
• mental and behavioral disorders that make it impossible for patients to participate in the study, drug and/or alcohol addiction;
• patients with malignant tumors including a history.