Treatment of patients with segmental bone tissue defects using mesenchymal stem cells enriched by extracellular vesicles

The aims of the project are to develop a technology for obtaining mesenchymal stem cells extracellular vesicles; to develop biomedical cell product based on mesenchymal stem cells enriched with own extracellular vesicles; to conduct the clinical trials of the biomedical cell product in the treatment of patients with segmental bone tissue defects

Inclusion Criteria:

• age 18-50 years;
• non-union fractures of the tubular bones of the upper limb;
• segmental defects of the bone tissue of the tubular bones of the upper limbs;
• absence of severe comorbidity worsening the patient's prognosis.

Exclusion Criteria:

• pregnancy;
• acute inflammatory processes;
• viral hepatitis B and C, HIV infection, syphilis and other viral and bacterial infections;
• autoimmune diseases;
• allergic reactions in the acute stage, established hypersensitivity to any component of the biomedical cell product;
• mental and behavioral disorders that make it impossible for patients to participate in the study, drug and/or alcohol addiction;
• patients with malignant tumors including a history.