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This multicenter observational study will explore the risk factors of early neurological deterioration(END) in patients with primary and to investigate the association between END and outcome.
Neurological deterioration affects approximately one-third of patients with primary intracerebral hemorrhage (ICH) and increases the risk of death and dependency. However, the risk factors of early neurological deterioration (END), such as biochemical parameters, neuroimaging, and systemic complications, are not well documented in primary ICH, and the effective predictors of END is unknown.
This multicenter observational study aims to seek out the risk factors of END in patients with primary ICH and to investigate the association between END and outcome.
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| Measure | Description | Time Frame |
|---|---|---|
| Early neurological deterioration (END) | END is defined as an increase in the total NIHSS score of ≥ 4 points within the first 48 h after admission | 48 hours after admission |
| Measure | Description | Time Frame |
|---|---|---|
| Late neurological deterioration (LND) | LND is defined as an increase in the total NIHSS score of ≥ 4 points between 48h and 7 days after admission | 7 days |
| Functional outcome | Functional outcome will be assessed with modified ranking scale(mRS).Poor outcome is defined as mRS 4-6 at follow-up |
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Inclusion Criteria:
Exclusion Criteria:
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Patients over 18 years old with primary intrcerebral hemorrhage will be enrolled consecutively.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Feng Gao, MD,PhD | Contact | 13588451471 | 2202012@zju.edu.cn | |
| Lusha Tong, MD,PhD | Contact | 15868171218 | 2310040@zju.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 2nd Affiliated Hospital, School of Medicine at Zhejiang University | Hangzhou | Zhejiang | 310000 | China |
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| 90 days, 1 year, 2 years after admission |
| Hematoma expansion | Hematoma volume expansion of at least 6 mL or 33% on a CT scan obtained 24 hours after admission compared with the entry scan. | 24 hours after admission |
| The quality of life | The quality of life will be assessed with the EuroQol-5D (EQ-5D) scale. | 90 days, 1 year, 2 years after admission |
| Depression status | Patient Health Questionnaire (PHQ)-9 scale will be evaluated, and higher scores means a worse status. | 90 days, 1 year, 2 years after admission |
| Cognitive function | Telephone Interview for Cognitive Status-Modified(TICS-m) scale will be evaluated via telephone interview. | 90 days, 1 year, 2 years after admission |
| ID | Term |
|---|---|
| D002543 | Cerebral Hemorrhage |
| D009461 | Neurologic Manifestations |
| D000083302 | Hemorrhagic Stroke |
| D006470 | Hemorrhage |
| ID | Term |
|---|---|
| D020300 | Intracranial Hemorrhages |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D020521 | Stroke |
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