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In anesthesia for ablation for cardiac arrhythmias, abrupt hemodynamic changes or fatal arrhythmias can be seen frequently. Remimazolam is a novel ultra-short acting benzodiazepine that provides good hemodynamic stability compared to conventional anesthetic agents. This study aims to investigate whether remimazolam reduces vasoactive agent use during cryo/radiofrequancy ablation under general anesthesia, compared to desflurane(RCT).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Remimazolam | Experimental | General anesthesia with remimazolam-remifentanil TIVA. |
|
| Desflurane | No Intervention | General anesthesia with maintaining with desflurane (induction:PPF, remifentanil CIV) |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Remimazolam besylate | Drug | Remimazolam besylate TIVA |
|
| Measure | Description | Time Frame |
|---|---|---|
| Vasopressor CIV | Vasopressor CIV or not | During anesthesia |
| Hypotension event | Hypotension event | During and after anesthesia |
| Vasopressor (total amount) | Norepinephrine equivalent dose | During anesthesia |
| Measure | Description | Time Frame |
|---|---|---|
| Induction time | Induction dose administration~LOC | Induction |
| Recovery time | Reversal agent administration~extubation | Recovery |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul national university Bundang hospital | Seongnam | Province (optional) | 13620 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38609684 | Derived | Yim S, Choi CI, Park I, Koo BW, Oh AY, Song IA. Remimazolam to prevent hemodynamic instability during catheter ablation under general anesthesia: a randomized controlled trial. Can J Anaesth. 2024 Aug;71(8):1067-1077. doi: 10.1007/s12630-024-02735-z. Epub 2024 Apr 12. |
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| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D002318 | Cardiovascular Diseases |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Adverse event | Adverse event (desaturation, vomiting, hypotension, bleeding, allergic or anaphylaxis, etc.) | During and after anesthesia (~24hr) |