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| ID | Type | Description | Link |
|---|---|---|---|
| 90SCIMS0013 | Other Grant/Funding Number | National Institute for Disability, Independent Living, and Rehabilitation Research |
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The purposes of the study are to quantify and compare relationships among acute changes in inflammatory markers and evoked pain sensitivity after a high-fat meal (HFM) challenge, compared to a moderate-fat meal challenge, and explore the influence of body composition on these responses, in individuals with chronic spinal cord injury
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Moderate Fat Meal, Followed by High Fat Meal Group | Experimental | Participants will receive a moderate fat meal, followed by a high fat meal approximately seven days apart. |
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| High Fat Meal, Followed by Moderate Fat Meal Group | Experimental | Participants will receive a high fat meal, followed by a moderate fat meal approximately seven days apart. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Moderate Fat Meal | Other | A liquid meal consisting of powdered protein and complex carbohydrates blended with coconut oil and peanut butter in ratios required to achieve the desired calorie and macronutrient distributions of a normal/moderate fat meal. |
| Measure | Description | Time Frame |
|---|---|---|
| peak change in Interleukin (IL)-6 | analysis of blood samples taken after ingestion of meal challenge for level of IL-6 in picograms/milliliter | at 40, 80, 160, 240, 320, and 400 minutes post meal ingestion |
| peak change in evoked pain sensitivity | measures of heat pain threshold (degrees Celsius), using the ascending method of limits via a 30mm2 surface thermode, obtained after ingestion of meal challenge | at 40, 80, 160, 240, 320, and 400 minutes post meal ingestion |
| Measure | Description | Time Frame |
|---|---|---|
| correlation coefficient between changes in IL-6 and evoked pain sensitivity | correlation coefficient for relationship between changes in IL-6 and heat pain thresholds across time | at 40, 80, 160, 240, 320, and 400 minutes post meal ingestion |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Elizabeth Felix, PhD | Contact | 305-243-4497 | efelix@med.miami.edu |
| Name | Affiliation | Role |
|---|---|---|
| Elizabeth Felix, PhD | University of Miami | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Miami | Recruiting | Coral Gables | Florida | 33146 | United States |
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| ID | Term |
|---|---|
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| High Fat Meal | Other | A liquid meal consisting of powdered protein and complex carbohydrates blended with coconut oil and peanut butter in ratios required to achieve the desired calorie and macronutrient distributions of a high-fat meal. |
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