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| ID | Type | Description | Link |
|---|---|---|---|
| HM12090 |
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The purpose of this research is to evaluate different methods of measuring body composition (amount of fat, muscle, bone, and water in your body) and to determine relationships between body composition and other medical problems associated with spinal cord injury (SCI).
A preliminary investigation in our laboratory has demonstrated the advantage of using 4-compartment modeling to assess body composition in SCI adults. In comparing body composition analyses techniques in 20 individuals with SCI, we found Total Error to be 8.0% with Dual X-ray Absorptiometry, 8.4% with hydrodensitometry, 11.5% with bioelectrical impedance analysis, and 21.8% with standard skinfold equations when compared to 4-compartment modeling, the currently accepted gold standard for body composition assessment. To date there is no gold standard for the determination of body composition in SCI individuals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Body Composition | 120 subjects will help create the regression models. The remaining 50 subjects will be recruited to determine if the equations work for the population. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Body composition | Other | Day 1 testing will incorporate underwater weighing, Bod Pod, DXA, BIA and anthropometrics. Day 2 will include RMR, MRI, and testing at GCRC |
|
| Measure | Description | Time Frame |
|---|---|---|
| To compare different methods of body composition analyses with the gold standard 4-compartment monitoring to determine accuracy and validity of those alternative, but less labor-intensive techniques. | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| To assess the relationship between % body fat, visceral fat, and markers of the metabolic syndrome, including Plasminogen Activator Inhibitor-1 (PAI-1), Thrombin-Activatable Fibrinolysis Inhibitor (TAFI), and high-sensitivity C-Reactive Protein (hsCRP) | 3 years | |
| To develop body composition regression equations that can be easily utilized in a clinical setting to estimate risk for the metabolic syndrome in persons with SCI. |
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Inclusion Criteria:
Exclusion Criteria:
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Individuals with a spinal cord injury of C5-L2 motor complete (AIS A&B only).
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Joshua Miller, MS | Contact | 804-675-6200 | Joshua.Miller@va.gov |
| Name | Affiliation | Role |
|---|---|---|
| David R Gater, MD, PhD | Hunter Holmes McGuire VAMC | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hunter Holmes McGuire Spinal Cord Injury Research Lab | Recruiting | Richmond | Virginia | 23249 | United States |
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D011782 | Quadriplegia |
| D010264 | Paraplegia |
| D013119 | Spinal Cord Injuries |
| D007333 | Insulin Resistance |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D001823 | Body Composition |
| C576348 | Creb3l2 protein, rat |
| ID | Term |
|---|---|
| D001669 | Biochemical Phenomena |
| D055598 | Chemical Phenomena |
| D008660 | Metabolism |
| D001824 | Body Constitution |
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|
| 3 years |
| To cross-validate the derived regression equations against the gold standard 4-compartment model in an independent group of persons with SCI. | 3 years |
| D010243 | Paralysis |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D006946 | Hyperinsulinism |
| D010829 |
| Physiological Phenomena |