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| ID | Type | Description | Link |
|---|---|---|---|
| NCI-2021-06437 | Registry Identifier | CTRP (Clinical Trial Reporting Program) |
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This clinical trial examines the influence of nicotine form, concentration, and e-liquid flavor on youth vaping behavior, as well as the heart and lung effects associated with this behavior. Electronic cigarette (e-cig) "vaping", while being promoted as a safer alternative to conventional cigarettes, has disproportionately attracted adolescents and young adults ("youth"). This trial may help researchers understand how nicotine form, concentration, and flavor affects people's vaping behaviors and health.
We will examine the influence of nicotine form and concentration, and e-liquid flavor on youth vaping behavior, nicotine uptake, abuse liability, toxicant exposure, and acute cardiovascular and pulmonary effects. Participants will complete 9 vaping sessions. Each vaping session will include a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. During the first session, participants will use their own e-cig and e-liquid; for the following 8 sessions, participants will vape a study-provided e-cig and e-liquid.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High concentration free-base nicotine (5%), Tobacco flavor | Experimental | Participate in vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
|
| High concentration nicotine salt (5%), Tobacco flavor | Experimental | Participate in vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
|
| High concentration free-base nicotine (5%), Menthol flavor | Experimental | Participate in vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
|
| High concentration nicotine salt (5%), Menthol flavor | Experimental | Participate in vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
|
| Low concentration free-base nicotine (1%), Tobacco flavor |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ECIG lab session 1 | Other | vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma Nicotine Concentration | Plasma nicotine concentration from blood drawn (3mL) 4 times in each session at baseline (0 min), 5 min., 10 min., 35 min. | 0, 5, 10, 35 min. |
| Puff Count | E-cig puff topography data collection for abuse liability. Number of puffs taken during the 30 minutes of ad libitum (as desired) vaping session. | 30 minutes |
| Average Puff Duration | E-cig puff topography data collection for abuse liability. Average puff duration during the 30 minutes of ad libitum (as desired) vaping session, in seconds. | 30 minutes |
| Average Puff Volume | E-cig puff topography data collection for abuse liability. The total volume of all puffs taken for each participant during the 30 minutes of ad libitum (as desired) vaping session, in ml. | 30 minutes |
| Lung Function Assessment | Lung function data will be collect using a handheld spirometry device. Physiological effects of pulmonary function collected from inhaled and exhaled breaths. Measures amount inhaled and how quickly exhaled. Change from baseline in forced expiratory volume (FEV) Change from baseline in forced vital capacity (FVC) | Baseline and 35 minutes |
| Airway Inflammation (NIOX VERO) | Physiological effects of pulmonary function collected from inhaled and exhaled breaths. Airway inflammation will be assessed using exhaled nitric oxide via the NIOX VERO. | 35 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Sensory E-Cigarette Expectancies Scale (SEES) | Background measures. Comprised of 9 items each of which range 0-4 from "never" to "almost always". The 3 subscales (enjoyment of taste and smell, pleasurable physical sensations, enjoyment of vapor cloud production) are the average of 3 items each; scores range from 0 to 4 with higher scores indicating greater enjoyment. | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Theodore L Wagener, PhD | Ohio State University Comprehensive Cancer Center | Principal Investigator |
| Marielle Brinkman, BS | Ohio State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39120901 | Derived | Cho YJ, Mehta T, Hinton A, Sloan R, Nshimiyimana J, Tackett AP, Roberts ME, Brinkman MC, Wagener TL. E-Cigarette Nicotine Delivery Among Young Adults by Nicotine Form, Concentration, and Flavor: A Crossover Randomized Clinical Trial. JAMA Netw Open. 2024 Aug 1;7(8):e2426702. doi: 10.1001/jamanetworkopen.2024.26702. |
| Label | URL |
|---|---|
| The Jamesline | View source |
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| ID | Title | Description |
|---|---|---|
| FG000 | Overall Population | Full population of participants evaluated at baseline |
| Title | Milestones | Reasons Not Completed | |||||
|---|---|---|---|---|---|---|---|
| Overall Study |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP_ICF | Yes | Yes | Yes | Study Protocol, Statistical Analysis Plan, and Informed Consent Form | Nov 21, 2022 |
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Participate in vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
|
| Low concentration nicotine salt (1%), Tobacco flavor | Experimental | Participate in vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
|
| Low concentration free-base nicotine (1%), Menthol flavor | Experimental | Participate in vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
|
| Low concentration nicotine salt (1%), Menthol flavor | Experimental | Participate in vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
|
| ECIG lab session 2 | Other | vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
|
| ECIG lab session 3 | Other | vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
|
| ECIG lab session 4 | Other | vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
|
| ECIG lab session 5 | Other | vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
|
| ECIG lab session 6 | Other | vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
|
| ECIG lab session 7 | Other | vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
|
| ECIG lab session 8 | Other | vaping session with e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
|
| Modified Cigarette Dependence Scale | Assess e-cigarette dependence. Scores range from 5 to 25 with higher scores indicating a greater level of dependence. | Baseline |
| Drug Effects/Liking Questionnaire | An adapted version of the Drug Effects/Liking Questionnaire will assess the desire and liking of UBMC and all three study products, positive and negative effects (i.e., side effects), and perceived strength and effectiveness. Five visual analog scale items ranging from 0 ('not at all') to 100 ('extremely') assessed wanting to smoke the product again, liking the product, enjoying the product, finding the product pleasurable and satisfying. | 35 minutes |
| Modified Cigarette Evaluation Questionnaire (mCEQ) | The modified Cigarette Evaluation Questionnaire (mCEQ) will assess subjective responses to e-cigarettes (e.g., reward, satisfaction). The 12-item mCEQ includes five subscales: Smoking Satisfaction, Psychological Reward, Aversion, Enjoyment of Respiratory Tract Sensations, and Craving Reduction, with items rated from 1 (not at all) to 7 (extremely likely). Items are averaged to create each of the subscales also ranging from 1 to 7 with higher values indicating greater levels of smoking satisfaction, psychological reward, aversion, enjoyment of respiratory tract sensations, an craving reduction. | 35 minutes |
| E-cigarette Purchase Task - Breakpoint | Behavioral economic demand Asks participants how much they would be willing to pay (ranging from 0¢ to $1,120) for a puff of their study product. Specifically they will be asked, "Thinking about the study product, how many puffs of e-cigarette would you smoke if they were each at the following prices?". Breakpoint is the first price of zero consumption. | 35 minutes |
| Tiffany-Drobes Questionnaire of Smoking Urges: Brief Form | E-cig craving/suppression of craving and withdraw will be measured using the Tiffany-Drobes Questionnaire of Smoking Urges (QSU): Brief Form with a modified version (replacing the word "cigarette" with "e-cigarette"). This is a 10-item measure where participants rate smoking/vaping-related items on a 7-point Likert scale ranging from 1 (strongly disagree) to 7 (strongly agree). Similar to previous studies, we will collapse the items into two previously identified factors (Factor 1: strong desire and intention to smoke/vape; Factor 2: anticipation of relief from withdrawal symptoms). Scores are calculated by summing the items and range from 5 to 35 for each of the factors with higher scores indicating greater craving to smoke/vape. | 0, 5, 10, 35 min. |
| Vascular Reactivity | Endothelial function will be collected through EndoPAT device. Specifically, the natural log of RHI, the reactive hyperemia index, will be recorded. The RHI (Reactive Hyperemia Index) or LnRHI (natural log of RHI) is the post-to-pre occlusion PAT™ signal ratio in the occluded arm, relative to the same ratio in the control arm, corrected for baseline vascular tone. Values less than 1.67 or higher than 0.51 are considered to be abnormal. | Pre-Vaping Session at Visit 1 |
| Usual Brand e-Cigarette |
|
| Low Concentration Free-base Nicotine (1%), Menthol Flavor |
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| Low Concentration Free-base Nicotine (1%), Tobacco Flavor |
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| Low Concentration Nicotine Salt (1%), Menthol Flavor |
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| Low Concentration Nicotine Salt (1%), Tobacco Flavor |
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| High Concentration Free-base Nicotine (1%), Menthol Flavor |
|
| High Concentration Free-base Nicotine (1%), Tobacco Flavor |
|
| High Concentration Nicotine Salt (1%), Menthol Flavor |
|
| High Concentration Nicotine Salt (1%), Tobacco Flavor |
|
| COMPLETED |
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| NOT COMPLETED |
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Demographics are presented as a whole for this cross-over study and not by product order due to the large number of product orderings used to randomize the presentation order of the 8 different products.
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| ID | Title | Description |
|---|---|---|
| BG000 | Overall Population | Full population of participants evaluated at baseline |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean | Standard Deviation | years |
| |||||||||||||||||
| Sex: Female, Male | Count of Participants | Participants |
| ||||||||||||||||||
| Race (NIH/OMB) | Count of Participants | Participants |
| ||||||||||||||||||
| Years of regular e-cigarette use | Two participants failed to provide the age at which they began regularly using e-cigarettes | Mean | Standard Deviation | years |
|
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Plasma Nicotine Concentration | Plasma nicotine concentration from blood drawn (3mL) 4 times in each session at baseline (0 min), 5 min., 10 min., 35 min. | Number analyzed is slightly different at each of the time points due to missing blood draws | Posted | Median | Inter-Quartile Range | ng/ml | 0, 5, 10, 35 min. |
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| ||||||||||||||||||||||||||||||||||||||||||||
| Primary | Puff Count | E-cig puff topography data collection for abuse liability. Number of puffs taken during the 30 minutes of ad libitum (as desired) vaping session. | Posted | Mean | Standard Deviation | Number of Puffs | 30 minutes |
| |||||||||||||||||||||||||||||||||||||||||||||||
| Primary | Average Puff Duration | E-cig puff topography data collection for abuse liability. Average puff duration during the 30 minutes of ad libitum (as desired) vaping session, in seconds. | Participants who attended the study visit and whose puff duration was able to be recorded. | Posted | Mean | Standard Deviation | seconds | 30 minutes | Puffs | Puffs |
| ||||||||||||||||||||||||||||||||||||||||||||
| Primary | Average Puff Volume | E-cig puff topography data collection for abuse liability. The total volume of all puffs taken for each participant during the 30 minutes of ad libitum (as desired) vaping session, in ml. | Participants who attended the study visit and whose puff volume was able to be recorded. | Posted | Mean | Standard Deviation | ml | 30 minutes | Puffs | Puffs |
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| Primary | Lung Function Assessment | Lung function data will be collect using a handheld spirometry device. Physiological effects of pulmonary function collected from inhaled and exhaled breaths. Measures amount inhaled and how quickly exhaled. Change from baseline in forced expiratory volume (FEV) Change from baseline in forced vital capacity (FVC) | Posted | Mean | Standard Deviation | Liters | Baseline and 35 minutes |
| |||||||||||||||||||||||||||||||||||||||||||||||
| Primary | Airway Inflammation (NIOX VERO) | Physiological effects of pulmonary function collected from inhaled and exhaled breaths. Airway inflammation will be assessed using exhaled nitric oxide via the NIOX VERO. | Posted | Mean | Standard Deviation | ppb | 35 minutes |
| |||||||||||||||||||||||||||||||||||||||||||||||
| Secondary | Sensory E-Cigarette Expectancies Scale (SEES) | Background measures. Comprised of 9 items each of which range 0-4 from "never" to "almost always". The 3 subscales (enjoyment of taste and smell, pleasurable physical sensations, enjoyment of vapor cloud production) are the average of 3 items each; scores range from 0 to 4 with higher scores indicating greater enjoyment. | Posted | Mean | Standard Deviation | score on a scale | Baseline |
|
| ||||||||||||||||||||||||||||||||||||||||||||||
| Secondary | Modified Cigarette Dependence Scale | Assess e-cigarette dependence. Scores range from 5 to 25 with higher scores indicating a greater level of dependence. | Participants who responded to all items on the modified cigarette dependence scale at baseline. | Posted | Mean | Standard Deviation | score on a scale | Baseline |
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| Secondary | Drug Effects/Liking Questionnaire | An adapted version of the Drug Effects/Liking Questionnaire will assess the desire and liking of UBMC and all three study products, positive and negative effects (i.e., side effects), and perceived strength and effectiveness. Five visual analog scale items ranging from 0 ('not at all') to 100 ('extremely') assessed wanting to smoke the product again, liking the product, enjoying the product, finding the product pleasurable and satisfying. | Posted | Mean | Standard Deviation | score on a scale | 35 minutes |
| |||||||||||||||||||||||||||||||||||||||||||||||
| Secondary | Modified Cigarette Evaluation Questionnaire (mCEQ) | The modified Cigarette Evaluation Questionnaire (mCEQ) will assess subjective responses to e-cigarettes (e.g., reward, satisfaction). The 12-item mCEQ includes five subscales: Smoking Satisfaction, Psychological Reward, Aversion, Enjoyment of Respiratory Tract Sensations, and Craving Reduction, with items rated from 1 (not at all) to 7 (extremely likely). Items are averaged to create each of the subscales also ranging from 1 to 7 with higher values indicating greater levels of smoking satisfaction, psychological reward, aversion, enjoyment of respiratory tract sensations, an craving reduction. | Posted | Mean | Standard Deviation | score on a scale | 35 minutes |
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| Secondary | E-cigarette Purchase Task - Breakpoint | Behavioral economic demand Asks participants how much they would be willing to pay (ranging from 0¢ to $1,120) for a puff of their study product. Specifically they will be asked, "Thinking about the study product, how many puffs of e-cigarette would you smoke if they were each at the following prices?". Breakpoint is the first price of zero consumption. | Posted | Median | Inter-Quartile Range | Dollars | 35 minutes |
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| Secondary | Tiffany-Drobes Questionnaire of Smoking Urges: Brief Form | E-cig craving/suppression of craving and withdraw will be measured using the Tiffany-Drobes Questionnaire of Smoking Urges (QSU): Brief Form with a modified version (replacing the word "cigarette" with "e-cigarette"). This is a 10-item measure where participants rate smoking/vaping-related items on a 7-point Likert scale ranging from 1 (strongly disagree) to 7 (strongly agree). Similar to previous studies, we will collapse the items into two previously identified factors (Factor 1: strong desire and intention to smoke/vape; Factor 2: anticipation of relief from withdrawal symptoms). Scores are calculated by summing the items and range from 5 to 35 for each of the factors with higher scores indicating greater craving to smoke/vape. | Participants who attended the study product visit and fully completed the QSU items | Posted | Mean | Standard Deviation | units on a scale | 0, 5, 10, 35 min. |
| ||||||||||||||||||||||||||||||||||||||||||||||
| Secondary | Vascular Reactivity | Endothelial function will be collected through EndoPAT device. Specifically, the natural log of RHI, the reactive hyperemia index, will be recorded. The RHI (Reactive Hyperemia Index) or LnRHI (natural log of RHI) is the post-to-pre occlusion PAT™ signal ratio in the occluded arm, relative to the same ratio in the control arm, corrected for baseline vascular tone. Values less than 1.67 or higher than 0.51 are considered to be abnormal. | Participants who attended the baseline study visit and whose endothelial function was able to be recorded with the EndoPAT device. | Posted | Mean | Standard Deviation | ratio | Pre-Vaping Session at Visit 1 |
|
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Up to 3 months
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Low Concentration Free-base Nicotine (1%), Menthol Flavor | Participate in vaping session with menthol flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. | 0 | 65 | 0 | 65 | 0 | 65 |
| EG001 | Low Concentration Free-base Nicotine (1%), Tobacco Flavor | Participate in vaping session with tobacco flavored low concentration free-base nicotine (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. | 0 | 64 | 0 | 64 | 0 | 64 |
| EG002 | Low Concentration Nicotine Salt (1%), Menthol Flavor | Participate in vaping session with menthol flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. | 0 | 61 | 0 | 61 | 0 | 61 |
| EG003 | Low Concentration Nicotine Salt (1%), Tobacco Flavor | Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. | 0 | 64 | 0 | 64 | 0 | 64 |
| EG004 | High Concentration Free-base Nicotine (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. | 0 | 64 | 0 | 64 | 0 | 64 |
| EG005 | High Concentration Free-base Nicotine (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. | 0 | 63 | 0 | 63 | 0 | 63 |
| EG006 | High Concentration Nicotine Salt (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. | 0 | 60 | 0 | 60 | 0 | 60 |
| EG007 | High Concentration Nicotine Salt (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. | 0 | 65 | 0 | 65 | 0 | 65 |
| EG008 | Usual Brand | Participate in vaping session with their usual brand e-cigarette including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. | 0 | 87 | 0 | 87 | 0 | 87 |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Theodore L. Wagener | OhioSUCCC | 614-366-4265 | Theodore.Wagener@osumc.edu |
| Sep 30, 2024 |
| Prot_SAP_ICF_000.pdf |
| ID | Term |
|---|---|
| D000072137 | Vaping |
| ID | Term |
|---|---|
| D012907 | Smoking |
| D001519 | Behavior |
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|
| Native Hawaiian or Other Pacific Islander |
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| Black or African American |
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| White |
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| More than one race |
|
| Unknown or Not Reported |
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| 5 Minutes |
|
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| 10 Minutes |
|
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| 35 Minutes |
|
|
| OG003 |
| Low Concentration Nicotine Salt (1%), Tobacco Flavor |
Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG004 | High Concentration Free-base Nicotine (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG005 | High Concentration Free-base Nicotine (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG006 | High Concentration Nicotine Salt (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG007 | High Concentration Nicotine Salt (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG008 | Usual Brand | Participate in vaping session with their usual brand e-cigarette including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
|
|
| OG003 | Low Concentration Nicotine Salt (1%), Tobacco Flavor | Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG004 | High Concentration Free-base Nicotine (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG005 | High Concentration Free-base Nicotine (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG006 | High Concentration Nicotine Salt (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG007 | High Concentration Nicotine Salt (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG008 | Usual Brand | Participate in vaping session with their usual brand e-cigarette including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
|
|
| OG003 | Low Concentration Nicotine Salt (1%), Tobacco Flavor | Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG004 | High Concentration Free-base Nicotine (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG005 | High Concentration Free-base Nicotine (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG006 | High Concentration Nicotine Salt (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG007 | High Concentration Nicotine Salt (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG008 | Usual Brand | Participate in vaping session with their usual brand e-cigarette including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
|
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| OG003 | Low Concentration Nicotine Salt (1%), Tobacco Flavor | Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG004 | High Concentration Free-base Nicotine (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG005 | High Concentration Free-base Nicotine (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG006 | High Concentration Nicotine Salt (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG007 | High Concentration Nicotine Salt (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG008 | Usual Brand | Participate in vaping session with their usual brand e-cigarette including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
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| OG003 | Low Concentration Nicotine Salt (1%), Tobacco Flavor | Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG004 | High Concentration Free-base Nicotine (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG005 | High Concentration Free-base Nicotine (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG006 | High Concentration Nicotine Salt (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG007 | High Concentration Nicotine Salt (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG008 | Usual Brand | Participate in vaping session with their usual brand e-cigarette including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
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| Title | Denominators | Categories | ||||
|---|---|---|---|---|---|---|
| Enjoyment of Taste and Smell |
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| Pleasurable Physical Sensations |
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| Enjoyment of Vapor Cloud Production |
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| Title | Denominators | Categories | ||||
|---|---|---|---|---|---|---|
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| OG003 | Low Concentration Nicotine Salt (1%), Tobacco Flavor | Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG004 | High Concentration Free-base Nicotine (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG005 | High Concentration Free-base Nicotine (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG006 | High Concentration Nicotine Salt (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG007 | High Concentration Nicotine Salt (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG008 | Usual Brand | Participate in vaping session with their usual brand e-cigarette including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
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| Low Concentration Nicotine Salt (1%), Menthol Flavor |
Participate in vaping session with menthol flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG003 | Low Concentration Nicotine Salt (1%), Tobacco Flavor | Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG004 | High Concentration Free-base Nicotine (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG005 | High Concentration Free-base Nicotine (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG006 | High Concentration Nicotine Salt (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG007 | High Concentration Nicotine Salt (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
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| OG003 | Low Concentration Nicotine Salt (1%), Tobacco Flavor | Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG004 | High Concentration Free-base Nicotine (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG005 | High Concentration Free-base Nicotine (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG006 | High Concentration Nicotine Salt (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG007 | High Concentration Nicotine Salt (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG008 | Usual Brand | Participate in vaping session with their usual brand e-cigarette including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
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| OG002 | Low Concentration Nicotine Salt (1%), Menthol Flavor | Participate in vaping session with menthol flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG003 | Low Concentration Nicotine Salt (1%), Tobacco Flavor | Participate in vaping session with tobacco flavored low concentration nicotine salt (1%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG004 | High Concentration Free-base Nicotine (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG005 | High Concentration Free-base Nicotine (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration free-base nicotine (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG006 | High Concentration Nicotine Salt (5%), Menthol Flavor | Participate in vaping session with menthol flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG007 | High Concentration Nicotine Salt (5%), Tobacco Flavor | Participate in vaping session with tobacco flavored high concentration nicotine salt (5%) e-liquid including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
| OG008 | Usual Brand | Participate in vaping session with their usual brand e-cigarette including a standardized, 5-minute, 10-puff vaping bout (30 seconds between each puff) followed by 30 minutes of ad libitum (as desired) vaping. |
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