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This study was planned to investigate the degree of effect of remimazolam on MEP compared to propofol when monitoring the motion-inducing potential (MEP).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Propofol-Remimazolam | Experimental | General anesthesia was induced and maintained with propofol, then switched to remimazolam after 60 minutes from incision. |
|
| Remimazolam-Propofol | Experimental | General anesthesia was induced and maintained with remimazolam, then changed to propofol after 60 minutes from incision. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Propofol | Drug | Anesthesia induction and maintenance with propofol 60 minutes later, change the maintenance drug to remimazolam |
|
| Measure | Description | Time Frame |
|---|---|---|
| Motor evoked potential (MEP), before cross-over | Amplitude and latency of MEP before cross-over | Intraoperative, just after confirmation of neuromuscular recovery, for 30 minutes |
| MEP, after cross-over | Amplitude and latency of MEP after cross-over | Intraoperative, 30 minutes after alteration of the maintenance drug, for 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Bispectral index | Bispectral index during MEP data collection | Intraoperative |
| Blood pressure | Blood pressure during MEP data collection |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sang Sik Choi, MD, PhD | Korea University Guro Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seok Kyeong Oh | Seoul | Gangnam-gu | 06294 | South Korea |
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| ID | Term |
|---|---|
| D013122 | Spinal Diseases |
| ID | Term |
|---|---|
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
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| ID | Term |
|---|---|
| D015742 | Propofol |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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|
| Remimazolam Besylate | Drug | Anesthesia induction and maintenance with remimazolam 60 minutes later, change the maintenance drug to propofol |
|
|
| Intraoperative |
| Heart rate | Heart rate during MEP data collection | Intraoperative |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |