Evaluating PVI Using CMR

CMR Characterization of Ablation Lesions Following Pulmonary Vein Isolation

Using state of the art cardiac magnetic resonance imaging techniques, characterization of ablation lesions in the early phase after pulmonary vein isolation ablation in atrial fibrillation patients, and relate findings to the ablation scar at 3 months follow up and atrial fibrillation-free survival at 1 year.

Inclusion Criteria:

• Adult patients (age ≥18 years old)
• Paroxysmal or persistent AF meeting guideline criteria.
• Anticipated PVI using index-guided radiofrequency ablation techniques.
• Availability of LGE-CMR images within 3 months before anticipated PVI.

Exclusion Criteria:

• History of catheter ablation
• History of cardiac surgery.
• History of chest radiation therapy
• Estimated glomerular filtration rate (eGFR) <45 ml/min/kg
• Known (or suspected) allergic reaction to gadolinium
• Contraindications for CMR (such as claustrophobia, certain implants, devices, high body mass index).
• Inability to schedule CMR <48h after PVI
• Long-term use of anti-inflammatory medication, except for the use of nonsteroidal anti-inflammatory drugs
• Autoimmune disease or chronic inflammatory illness.
• Pregnancy of breast feeding