Evaluation of the Incidence of Cerebral Lesions Post Pulmonary Vein Ablation Catheter (PVAC)

Evaluate Reduction in Asymptomatic Cerebral Embolism

The purpose of the study is to determine the rate of diffusion weighted (DW)-MRI cerebral lesions following a Pulmonary Vein Ablation Catheter (PVAC) ablation procedure performed using best practices, including optimized procedural techniques and anti-coagulation therapy.

Inclusion Criteria:

• Subject is at least 18 years old
• Subject has been diagnosed with atrial fibrillation (AF)
• Subject is indicated for a pulmonary vein ablation using PVAC
• Subject (or subject's legally authorized representative) is able and and willing to give informed consent.

Exclusion Criteria:

• Subject has permanent AF
• Subject has a left atrial thrombus detected on TEE
• Subject has had a prior left atrial ablation
• Subject has a intracardiac thrombus
• Subject is contraindicated for Warfarin (Coumadin)
• Subject has a cardiac valve prosthesis
• Subject has a significant congenital heart defect corrected or not including atrial septal defects or pulmonary vein abnormalities but not including minor PFO)
• Subject has presence of any pulmonary vein stents
• Subject has presence of any pre-existing pulmonary vein stenosis
• Subject has had a cerebral ischemic event (strokes or transient ischemic attacks [TIA]) which occurred during the 6 month interval preceding the Consent Date
• Subject is a woman known to be pregnant
• Subject is unwilling or unable to comply fully with study procedures and follow-up