Precision Ablation For Pulmonary Vein Isolation: Targeting Pulmonary Vein Myocardial Sleeves (PVMS) With Omnipolar Mapping Technology

Precision Ablation For Pulmonary Vein Isolation: Targeting Pulmonary Vein Myocardial Sleeves With Omnipolar Mapping Technology - A Randomized Pilot Trial

The purpose of this study is to compare procedural times and Radiofrequency (RF)applications required for Pulmonary vein myocardial sleeves targeted pulmonary vein ablation (PVS-PVI) , to compare the efficacy of PVS-PVI , to compare the safety of PVS-PVI and to assess other clinical outcomes of PVS-PVI in individuals with symptomatic paroxysmal Atrial fibrillation (AF) using Omnipolar Technology with conventional Wide area circumferential ablation (WACA).

Inclusion Criteria:

• Symptomatic paroxysmal AF refractory to at least one Class I or Class III antiarrhythmic medication, intolerance to antiarrhythmic medications, or a preference to not trial antiarrhythmic medications
• A minimum of one documented AF episode via 12-lead ECG, Holter monitor, or loop recorder
• Capability to provide informed consent

Exclusion Criteria:

• Persistent or permanent AF
• Prior history of catheter or surgical ablation for AF or left atrial ablation for atypical flutter
• Reversible causes of AF
• Congenital heart disease
• Significant valve disease (moderate or severe mitral/aortic stenosis or regurgitation)
• Pregnancy
• Known presence of intracardiac thrombus
• Systemic oral anticoagulation therapy contraindicated, including a history of heparin-induced thrombocytopenia
• Broad vortex-like connections and no clear PVMS to be targeted