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| ID | Type | Description | Link |
|---|---|---|---|
| K01HL145021 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
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The present study will examine cardiovascular, metabolic, and neural responses to acute psychological stress using a cross-sectional approach.
All participants in this study will undergo an acute psychological stress paradigm, consisting of two acute psychological stress tasks (MSIT and Stoop). There is no formal randomization since al participants are randomized to undergo the acute psychological stress tasks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute psychological stress task (MSIT; Stroop) | Experimental | Multi-source interference task (MSIT; Stroop) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acute psychological stress | Other | Experimental: Acute psychological stress Two, acute-psychological stress tasks known to reliably elicit a cardiovascular responses (Multi-source interference task; Stroop). |
| Measure | Description | Time Frame |
|---|---|---|
| Stressor-evoked Oxygen Consumption in mL/(kg·Min) (Stress - Baseline) | Stressor-evoked oxygen consumption. (Oxygen consumption during acute psychological stress task - Oxygen consumption during resting baseline). | 18 minutes (approximately 9 minutes for each task) |
| Heart Rate (Bpm) Measured by Electrocardiogram | Stressor-evoked heart rate. (Heart rate during acute psychological stress task - Heart rate during resting baseline). | 18 minutes (approximately 9 minutes for each stress task) |
| Neural Activity Measured by fMRI | Stressor-evoked neural activity. Incongruent-vs-Congruent t at the group-level, filtered at 0.05 after FDR correction and with a cluster extent of 50 voxels. | 18 minutes (approximately 9 minutes for each stress task). |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Annie Ginty, PhD | Baylor University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Baylor University | Waco | Texas | 76799 | United States |
There is no plan to share IPD with other rsearchers.
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All participants engaged in the acute psychological stress task.
Recruited in Waco, Texas area
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| ID | Title | Description |
|---|---|---|
| FG000 | Acute Psychological Stress | Participants will undergo an acute psychological stress task that has been shown to elicit neural, cardiovascular, and psychological (feelings of stressfulness) responses. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
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| ID | Title | Description |
|---|---|---|
| BG000 | Acute Psychological Stress | Participants will undergo an acute psychological stress task that has been shown to elicit neural, cardiovascular, and psychological (feelings of stressfulness) responses. Acute psychological stress: Participants will undergo an acute psychological stress task that has been shown to elicit neural, cardiovascular, and psychological (feelings of stressfulness) responses. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Stressor-evoked Oxygen Consumption in mL/(kg·Min) (Stress - Baseline) | Stressor-evoked oxygen consumption. (Oxygen consumption during acute psychological stress task - Oxygen consumption during resting baseline). | Posted | Mean | Standard Deviation | mL/(kg·min) | 18 minutes (approximately 9 minutes for each task) |
|
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4 total hours (participants were monitored during each of the 2 hour lab visits).
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Acute Psychological Stress | Participants will undergo an acute psychological stress task that has been shown to elicit neural, cardiovascular, and psychological (feelings of stressfulness) responses. Acute psychological stress: Participants will undergo an acute psychological stress task that has been shown to elicit neural, cardiovascular, and psychological (feelings of stressfulness) responses. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Debroah Holland | Baylor University | (254) 710-1438 | Deborah_L_Holland@baylor.edu |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Feb 20, 2020 | Dec 20, 2022 | Prot_SAP_000.pdf |
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| Participants |
|
| Age, Continuous | Mean | Standard Deviation | years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Ethnicity (NIH/OMB) | Count of Participants | Participants |
|
| Race (NIH/OMB) | Count of Participants | Participants |
|
| Region of Enrollment | Count of Participants | Participants |
|
|
| Primary | Heart Rate (Bpm) Measured by Electrocardiogram | Stressor-evoked heart rate. (Heart rate during acute psychological stress task - Heart rate during resting baseline). | Data loss for 3 participants due to equipment malfunction. | Posted | Mean | Standard Deviation | beats per minute (bpm) | 18 minutes (approximately 9 minutes for each stress task) |
|
|
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| Primary | Neural Activity Measured by fMRI | Stressor-evoked neural activity. Incongruent-vs-Congruent t at the group-level, filtered at 0.05 after FDR correction and with a cluster extent of 50 voxels. | Participants who have full data for both acute psychological stress tasks during fMRI scanning. | Posted | Mean | Standard Error | BOLD signal (Incon - Con) | 18 minutes (approximately 9 minutes for each stress task). |
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| 0 |
| 170 |
| 0 |
| 170 |
| 0 |
| 170 |
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| Title | Measurements |
|---|---|
|
| L Frontal_Inf_Tri (stroop) |
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| L Parietal_Inf2 (stroop) |
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| R Insula (stroop) |
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| R Frontal_Inf_Oper (stroop) |
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| R Vermis (stroop) |
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| R Thalamus (stroop) |
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| L Precuneus2 (stroop) |
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| L ParaHippocampal2a (stroop) |
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| L Angular2 (stroop) |
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| L Frontal_Med_Orb2 (stroop) |
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| L Frontal_Sup2 (stroop) |
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| L ParaHippocampal2 (stroop) |
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| R ParaHippocampal2 (stroop) |
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| R Precentral2 (stroop) |
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| R Rolandic_Oper2 (stroop) |
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| R Angular2 (stroop) |
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| R Amygdala2 (stroop) |
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| R Frontial_Sup2 (stroop) |
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| R Cerebelum_Crus2 (stroop) |
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| L Parietal_Inf (MSIT) |
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| R Parietal_Inf (MSIT) |
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| R Angular (MSIT) |
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| L Supp_Motor_Area (MSIT) |
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| L Frontal_Inf_Oper (MSIT) |
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| R Calcarine (MSIT) |
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| R Frontal_Inf_Oper (MSIT) |
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| R Insula (MSIT) |
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| R Frontal_Mid (MSIT) |
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| L Thalamus (MSIT) |
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| L Frontal_Mid_Orb (MSIT) |
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| L Cingulum_Mid2 (MSIT) |
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| L Angular2 (MSIT) |
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| L Frontal_Sup2 (MSIT) |
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| L Frontal_Med_Orb2 (MSIT) |
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| R Hippocampus2 (MSIT) |
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| R Angular2 (MSIT) |
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| R Insula2 (MSIT) |
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| R Temporal_Mid2 (MSIT) |
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| R Cerebellum_Crus2 (MSIT) |
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| R Precentral2 (MSIT) |
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| L Cerebellum_Crus2 (MSIT) |
|