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Transcranial infrared laser stimulation is a non-invasive neuromodulation technique. The study will examine the effect of transcranial infrared laser stimulation on cardiovascular and metabolic responses to stress.
Physiological responses to stress may be a potential pathway by which psychological stress relates to cardiovascular disease. Disproportionate (metabolically exaggerated) stressor-evoked cardiovascular reactions may accelerate atherosclerosis or influence risk of greater cardiovascular disease endpoints. The aim of this project is to use an experimental approach to examine if neuromodulation (transcranial infrared laser stimulation) alters stressor-evoked metabolic and cardiovascular responses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sham | Sham Comparator | Participants will receive sham laser to the right forehead. |
|
| Transcranial infrared laser stimulation | Active Comparator | Participants will receive transcranial infrared laser stimulation to the right forehead. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low-level laser therapy (LLLT) | Other | Sham Comparator: Participants will receive 8 counts of 60 seconds of the same laser to the right forehead, however the laser power will be turned off and will be 0 Watts. Transcranial infrared laser stimulation: Participants will receive 8 counts of 60 seconds of transcranial infrared laser stimulation to the right forehead. The wavelength will be 1064 nm and the laser power will be 3.4 Watts. |
| Measure | Description | Time Frame |
|---|---|---|
| Oxygen consumption in response to acute psychological stress | This measurement takes into account oxygen consumption at baseline and during the stress task. | Immediately following intervention (up to 60 minutes) |
| Heart rate in response to acute psychological stress | This measurement takes into account heart rate at baseline and during the stress task. | Immediately following intervention (up to 60 minutes) |
| Additional heart rate in response to acute psychological stress | This measurement takes into account additional heart rate at baseline and during stress. | Immediately following intervention (up to 60 minutes) |
| Measure | Description | Time Frame |
|---|---|---|
| Perceived stress | Ratings of perceived stressfulness (1 = not at all stressful, 7 = very stressful) of the acute psychological stress task | Immediately following intervention (up to 60 minutes) |
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Inclusion Criteria:
18-30 years old
Exclusion Criteria:
History of a diagnosed chronic medical or neurological disorder Current pregnancy Current illness or infection (e.g., cold, flu) Any condition that would prohibit them from engaging in physical exercise
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Annie T. Ginty | Recruiting | Waco | Texas | 76798 | United States |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | May 18, 2024 | |
| Reset | Sep 20, 2024 | |
| Release | Jun 22, 2025 | |
| Reset | Jul 10, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| May 18, 2024 | Sep 20, 2024 | |||
| Jun 22, 2025 |
| ID | Term |
|---|---|
| D015775 | Fractures, Stress |
| ID | Term |
|---|---|
| D050723 | Fractures, Bone |
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| D028022 | Low-Level Light Therapy |
| ID | Term |
|---|---|
| D053685 | Laser Therapy |
| D013812 | Therapeutics |
| D010789 | Phototherapy |
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| Jul 10, 2025 |