Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Yonsei University | OTHER |
Not provided
Not provided
Not provided
The purpose of this study is to optimize the dosage regimen of drugs in patients during during Extracorporeal Membrane Oxygenation (ECMO) by population pharmacokinetic modeling.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients udergoing ECMO | Population who have been taking antibiotics or antiplatelets or sedatives/analgesics during Extracorporeal Membrane Oxygenation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Residual blood | Other | Residual blood samples(1~2 cc) at each sampling time are collected from all subjects while using ECMO for drug concentration assays(LC-MS/MS etc.). |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pharmacokinetic parameters | Volume of distribution | Day 0 to day 3 during ECMO, Day 0 to day 3 after removing ECMO |
| Pharmacokinetic parameters | Clearance | Day 0 to day 3 during ECMO, Day 0 to day 3 after removing ECMO |
| Pharmacokinetic parameters | Absorption rate (if oral drugs) | Day 0 to day 3 during ECMO, Day 0 to day 3 after removing ECMO |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Patients who are taking levofloxacin, meropenem, vancomycin, cefepime, midalzolam, dexmedetomidine, propofol, clopidogrel, ticagrelor, or prasugrel while underdoing Extracorporeal Membrane Oxygenation
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jin Wi, Prof | Contact | +82 32-460-3663 | caesar@gilhospital.com |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gacheon University Gil Medical Center | Recruiting | Incheon | 21565 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22520488 | Background | Shekar K, Fraser JF, Smith MT, Roberts JA. Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation. J Crit Care. 2012 Dec;27(6):741.e9-18. doi: 10.1016/j.jcrc.2012.02.013. Epub 2012 Apr 18. | |
| 25032748 | Background | Shekar K, Mullany DV, Thomson B, Ziegenfuss M, Platts DG, Fraser JF. Extracorporeal life support devices and strategies for management of acute cardiorespiratory failure in adult patients: a comprehensive review. Crit Care. 2014 May 9;18(3):219. doi: 10.1186/cc13865. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Residual whole blood
| 23190792 | Background | Shekar K, Roberts JA, Welch S, Buscher H, Rudham S, Burrows F, Ghassabian S, Wallis SC, Levkovich B, Pellegrino V, McGuinness S, Parke R, Gilder E, Barnett AG, Walsham J, Mullany DV, Fung YL, Smith MT, Fraser JF. ASAP ECMO: Antibiotic, Sedative and Analgesic Pharmacokinetics during Extracorporeal Membrane Oxygenation: a multi-centre study to optimise drug therapy during ECMO. BMC Anesthesiol. 2012 Nov 28;12:29. doi: 10.1186/1471-2253-12-29. |