Pharmacokinetics in Extracorporeal Membrane Oxygenation

Pharmacokinetics of Antibiotics, Sedative and Analgesic During Extracorporeal Membrane Oxygenation

The main purpose of the present study is to investigate the risk factors that affect drug pharmacokinetic (PK) during extracorporeal membrane oxygenation (ECMO). To advance understanding of PK variance and improve the patients outcomes during ECMO.

Ex vivo experiments for drug stability testing and ECMO circuits testing in animal models.PK studies in healthy animals and critically ill animal models with or without ECMO to define the PK alterations. Clinical PK studies in critically ill patients on ECMO.

Inclusion Criteria:

• Patients who are undergoing ECMO for respiratory and or cardiac dysfunction
• Clinical indication for the antibiotics
• Clinical indication for the sedatives and analgesics

Exclusion Criteria:

• No consent
• Known allergy to study drug
• Pregnancy
• Massive fluid resuscitation (>50% blood volume transfused) in the previous 8 hours.
• Therapeutic plasma exchange in the preceding 24 hours