PK/PD of the Sedatives, Analgesics and Antibiotics in Patients Receiving ECMO

Pharmacokinetics/Pharmacodynamics of the Sedatives, Analgesics and Antibiotics in Patients Receiving Extracorporeal Membrane Oxygenation (ECMO)

It is a multi-center, open-label, observational study aimed to understand the pharmacokinetics and pharmacodynamics of the commonly used sedative, analgesic and antibiotic drugs in adult patients supported with extracorporeal membrane oxygenation (ECMO), by measuring the plasma concentrations and the clinical effect of dexmedetomidine, midazolam, butorphanol, remifentanil, sufentanil, propofol, linezolid, tigecycline, teicoplanin, caspofungin, voriconazole and meropenem.

Inclusion Criteria:

• Patient given the sedatives, analgesics and antibiotics of interest during ECMO.
• Age from 18 to 85 years old.
• Multiple blood sampling is acceptable.

Exclusion Criteria:

• Patients who are allergic to the investigated drugs.
• Patients who are pregnant.