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| ID | Type | Description | Link |
|---|---|---|---|
| 30064 | Other Grant/Funding Number | Brain & Behavior Research Foundation |
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| Name | Class |
|---|---|
| Brain & Behavior Research Foundation | OTHER |
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This study will assess the impact of traveling wave transcranial alternating current stimulation (tACS) on working memory performance in adults.
Transcranial alternating current stimulation (tACS) can non-invasively alter neuroelectric activity in the brain by applying weak time-varying electric currents via the scalp. Complex patterns of electric brain activity can take the form of traveling waves - spatially coherent brain rhythms that gradually propagate through the neocortex. Traveling waves are crucial for the temporal coordination of informational flow in the brain. Using the novel traveling-wave transcranial alternating current stimulation (tACS) approach, the investigators will explore the effects of frontal-to-parietal and parietal-to-frontal traveling waves on working memory performance and brain electrophysiology in adults.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Frontoparietal Slow Theta Stimulation | Experimental | Participants will receive multi-electrode transcranial alternating current stimulation over the prefrontal and parietal brain regions that induces frontal-to-parietal traveling wave at the frequency of 4 Hz with the intensity of up to 2 mA and duration up to 20 min. |
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| Frontoparietal Fast Theta Stimulation | Experimental | Participants will receive multi-electrode transcranial alternating current stimulation over the prefrontal and parietal brain regions that induces frontal-to-parietal traveling wave at the frequency of 7 Hz with the intensity of up to 2 mA and duration up to 20 min. |
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| Parietofrontal Slow Theta Stimulation | Experimental | Participants will receive multi-electrode transcranial alternating current stimulation over the prefrontal and parietal brain regions that induces parietal-to-frontal traveling wave at the frequency of 4 Hz with the intensity of up to 2 mA and duration up to 20 min. |
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| Parietofrontal Fast Theta Stimulation | Experimental | Participants will receive multi-electrode transcranial alternating current stimulation over the prefrontal and parietal brain regions that induces parietal-to-frontal traveling wave at the frequency of 7 Hz with the intensity of up to 2 mA and duration up to 20 min. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial alternating current stimulation (tACS) | Device | Non-invasive, multi-electrode transcranial alternating current stimulation (tACS) over frontal and parietal brain areas. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in working memory performance | Changes in working memory performance (% of correct responses) as measured with the standardized N-back working memory task during active stimulation relative to pre-stimulation performance. | Immediate effect during stimulation |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in reaction time | Changes in reaction time (milliseconds) as measured using the standardized N-back working memory task during active stimulation relative to pre-stimulation performance. | Immediate effect during stimulation |
| Changes in electroencephalographic (EEG) connectivity |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ivan Alekseichuk, PhD | University of Minnesota | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Minnesota | Minneapolis | Minnesota | 55455 | United States |
Full or partial access to the preprocessed data will be provided upon the request to the faculty / research staff of recognized research, medical, and educational institutions for educational and scientific purposes. The request should be sent via an institutional email and will be stored with the study materials. The request should include a short description of the scientific or educational aims.
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Data will be shared only upon request after the study has ended (within 6 months).
To receive access, the study investigators need to be contacted via an institutional e-mail including a short description of the scientific or educational aims.
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Feb 6, 2026 | |
| Reset | Feb 24, 2026 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Feb 6, 2026 | Feb 24, 2026 | |||
| Mar 16, 2026 |
| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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Changes in electroencephalographic (EEG) connectivity in theta band (in normalized units) after transcranial electric stimulation relative to pre-stimulation periods. |
| Five minutes post-stimulation |
| Apr 3, 2026 |
| 7 |
| Apr 29, 2026 | May 21, 2026 | 8 |
| Jun 2, 2026 | Jun 25, 2026 | 9 |
| Jul 1, 2026 |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |