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This clinical trial aims to explore the effect of dual-site theta-gamma cross-frequency coupled transcranial alternating current stimulation in the frontal and parietal region on the working memory ability of patients with cognitive impairment after stroke, and to evaluate the safety of this protocol. The main purpose is to answer the following question: Can dual-site cross-frequency coupled tACS in the frontal parietal region improve the performance of working memory and cognitive-motor dual tasks in stroke patients? What is its mechanism of action? Researchers will compare the effects of real cross-frequency coupled stimuli and sham stimuli to see if the real stimuli can bring better results to patients. Participants will receive 40 minutes of real or sham electrical stimulation once a day for 5 consecutive days. Clinical evaluations (cognitive scales) and fNIRS were conducted respectively before and after stimulation to record the relevant brain activities at rest and during cognitive tasks
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| real tACS | Experimental |
| |
| sham tACS | Sham Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| occupational therapy | Behavioral | occupational therapy (especially cognitive therapy) 40min a day for 5 days |
|
| Measure | Description | Time Frame |
|---|---|---|
| n-back task accuracy rate | n-back task record accuracy rate | Baseline and 5-days |
| n-back task reaction time | n-back task record reaction time | Baseline and 5-days |
| function connectivity during n-back task | n-back task with fNIRS to record Oxy-Hb Concentration | Baseline and 5-days |
| Verbal fluency test(VFT)accuracy rate | VFT task record accuracy rate | Baseline and 5-days |
| Verbal fluency test(VFT)reaction time | VFT task record reaction time | Baseline and 5-days |
| function connectivity during Verbal fluency test(VFT) | VFT task with fNIRS to record Oxy-Hb Concentration | Baseline and 5-days |
| Measure | Description | Time Frame |
|---|---|---|
| Montreal Cognitive Assessment(MoCA) | MoCA scale(score 0-30, the higher score means the better function) | Baseline and 5-days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jingting Li | Contact | +86 13560365827 | lijt53@mail.sysu.edu.cn | |
| Hanjun Liu | Contact | +86 15920175118 | lhanjun@mail.sysu.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University | Guangzhou | Guangdong | China |
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| real tACS | Other | real theta-gamma CFC tACS for 40min a day for 5 days during cognitive therapy |
|
| sham tACS | Other | sham theta-gamma CFC tACS for 40min a day for 5 days during cognitive therapy |
|
| ID | Term |
|---|---|
| D020521 | Stroke |
| D003072 | Cognition Disorders |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D009788 | Occupational Therapy |
| ID | Term |
|---|---|
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
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