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To determine if the mean elasticity value (measured in kilopascals, kPa) of a patient's endometrium, myometrium and cervix in a sonographically normal appearing uterus predict frozen embryo transfer (FET) success and long term reproductive outcomes when measured the day prior to FET.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Women undergoing euploid, single frozen embryo transfer | Women age 18yo-45yo undergoing euploid, single, frozen embryo transfer with sonographically normal appearing uterus without uterine factor infertility |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Uterine Elastography | Diagnostic Test | Shear wave elastography data will be obtained at the transvaginal ultrasound visit the day prior to frozen embryo transfer |
|
| Measure | Description | Time Frame |
|---|---|---|
| Sustained Implantation Rate | number of fetal heart beats at time of discharge ultrasound | 6 weeks after embryo transfer |
| Measure | Description | Time Frame |
|---|---|---|
| Chemical Pregnancy | Positive serum bHCG level | 8-10 days after embryo transfer |
| Clinical Pregnancy | presence of gestational sac on ultrasound |
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Inclusion Criteria:
Exclusion Criteria:
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All patients presenting to one of our offices for an ultrasound the day prior to embryo transfer will be reviewed for inclusion. Patients will be undergoing euploid, single, frozen embryo transfer.
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| Name | Affiliation | Role |
|---|---|---|
| Marie Werner, MD | Reproductive Medicine Associates of New Jersey | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Reproductive Medicine Associates of New Jersey | Basking Ridge | New Jersey | 07920 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39999405 | Derived | Margolis C, Garrido N, Roberts L, Reig A, Gill P, Willson S, Genovese H, Barrett F, Zuckerman C, Whitehead C, Bergh P, Seli E, Werner M. Mapping the way to successful euploid frozen embryo transfer: a prospective pilot study of uterine elastography. Hum Reprod. 2025 May 1;40(5):895-903. doi: 10.1093/humrep/deaf029. |
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| ID | Term |
|---|---|
| D007247 | Infertility, Female |
| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| 2-4 weeks after embryo transfer |
| Clinical Pregnancy Loss | loss of gestational sac, yolk sac, fetal pole, fetal heart beat on ultrasound after being present | 2-40 weeks after embryo transfer |
| D000091662 | Genital Diseases |
| D007246 | Infertility |